NL-OMON53227RecruitingNot Applicable
The effect of total knee replacement surgery on immune functioning in elderly - Immu-KNEE-ty
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Wageningen Universiteit
- Enrollment
- 14
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 65 to 99 (—)
Inclusion Criteria
- •- Planned for primary total knee replacement surgery
- •- Aged 65 years or over
- •- Diagnosed with osteoarthritis
- •- ASA Physical Status Classification of II or III
- •- Scheduled for general anesthesia
- •- Willing to donate a blood sample at 5 different timepoints
- •- Able to give written informed consent
Exclusion Criteria
- •- Daily use of high doses NSAIDs within the 14 days before inclusion: Defined as higher than maintenance dose in the *farmacotherapeutisch kompas*. For example: acetylsalicylic acid > 4 g /day; diclofenac > 75 mg/day; naproxen > 500 mg/day; ibuprofen> 1600 mg/day; celecoxib > 200 mg/day - Use of systemic corticosteroids - Use of antibiotics within the 14 days before inclusion - Current diagnosis of cancer - Diagnosed with a primary immunodeficiency disorder (e.g., Severe Combined Immunodeficiency (SCID), Common Variable Immune Deficiency (CVID), X-linked agammaglobulinemia, selective immunoglobulin A deficiency, chronic granulomatous disease) - Vaccination (e.g., immunization against COVID-19, influenza, pneumonia, and travel-related infections) within the 14 days before inclusion and during the study period - Current participation in other scientific research
Investigators
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