NL-OMON53227
Recruiting
Not Applicable
The effect of total knee replacement surgery on immune functioning in elderly - Immu-KNEE-ty
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- immunosenescentie
- Sponsor
- Wageningen Universiteit
- Enrollment
- 14
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Planned for primary total knee replacement surgery
- •\- Aged 65 years or over
- •\- Diagnosed with osteoarthritis
- •\- ASA Physical Status Classification of II or III
- •\- Scheduled for general anesthesia
- •\- Willing to donate a blood sample at 5 different timepoints
- •\- Able to give written informed consent
Exclusion Criteria
- •\- Daily use of high doses NSAIDs within the 14 days before inclusion: Defined as higher than maintenance dose in the \*farmacotherapeutisch kompas\*. For example: acetylsalicylic acid \> 4 g /day; diclofenac \> 75 mg/day; naproxen \> 500 mg/day; ibuprofen\> 1600 mg/day; celecoxib \> 200 mg/day \- Use of systemic corticosteroids \- Use of antibiotics within the 14 days before inclusion \- Current diagnosis of cancer \- Diagnosed with a primary immunodeficiency disorder (e.g., Severe Combined Immunodeficiency (SCID), Common Variable Immune Deficiency (CVID), X\-linked agammaglobulinemia, selective immunoglobulin A deficiency, chronic granulomatous disease) \- Vaccination (e.g., immunization against COVID\-19, influenza, pneumonia, and travel\-related infections) within the 14 days before inclusion and during the study period \- Current participation in other scientific research
Outcomes
Primary Outcomes
Not specified
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