Verticality Perception in Stroke Patients

Not Applicable

• Conditions: Verticality Perception in Stroke
• Interventions: Other: presentation of visual vertical

• Registration Number: NCT02184923
• Lead Sponsor: University of Zurich

Brief Summary

The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright.The strategy of this research is to quantify changes in verticality perception after unilateral lesions along the central graviceptive pathways and to assess the frequency and pattern of abnormal verticality perception in patients with acute stroke (ischemic or hemorrhagic). Our underlying hypothesis is that screening for erroneous verticality perception by use of a mobile device assessing the subjective visual vertical (SVV) during the acute phase (i.e., within 24-48 hours after symptom onset) reliably identifies those patients with defects. Early detection of deficits in verticality perception may help to initiate balance physiotherapy early.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-07-03
• Study First Submitted QC: 2014-07-04
• Study First Posted: 2014-07-09
• Study Start: 2014-08
• Primary Completion: 2017-12-31
• Status Verified: 2019-12
• Last Update Submitted: 2020-01-06
• Last Update Posted: 2020-01-07
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

1. ages 18-90 years
2. informed consent
3. for group 1: acute (i.e. symptom onset <3 days ago) lateralized ischemia or hemorrhage as confirmed by clinical examination and / or brain imaging (CT or MRI).
4. absence of exclusion criteria

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Exclusion Criteria

1. history of a peripheral-vestibular deficit
2. disturbed consciousness
3. severe sensory or motor aphasia
4. visual field deficits
5. other neurological or systemic disorder which can cause dementia or cognitive dysfunction
6. intake of antidepressants, sedatives, or neuroleptics

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
verticality measurements	presentation of visual vertical	-

Primary Outcome Measures

Name	Time	Method
Accuracy of verticality perception	during the measurement period (10 minutes)

Secondary Outcome Measures

Name	Time	Method
Test-re-test reliability of verticality perception	from session 1 (day 0) to session 2 (day 1)

Trial Locations

Locations (1)

University Hospital Zurich; 🇨🇭 Zurich, ZH, Switzerland