Verticality Perception in Patients With Acute Lateralized Lesions Along the Central Graviceptive Pathways- Acute Assessment on the Ward and the Stroke Center
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- University of Zurich
- Enrollment
- 130
- Locations
- 2
- Primary Endpoint
- Accuracy of verticality perception
Study Overview
Brief Summary
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright.The strategy of this research is to quantify changes in verticality perception after unilateral lesions along the central graviceptive pathways and to assess the frequency and pattern of abnormal verticality perception in patients with acute stroke (ischemic or hemorrhagic). Our underlying hypothesis is that screening for erroneous verticality perception by use of a mobile device assessing the subjective visual vertical (SVV) during the acute phase (i.e., within 24-48 hours after symptom onset) reliably identifies those patients with defects. Early detection of deficits in verticality perception may help to initiate balance physiotherapy early.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •ages 18-90 years
- •informed consent
- •for group 1: acute (i.e. symptom onset <3 days ago) lateralized ischemia or hemorrhage as confirmed by clinical examination and / or brain imaging (CT or MRI).
- •absence of exclusion criteria
Exclusion Criteria
- •history of a peripheral-vestibular deficit
- •disturbed consciousness
- •severe sensory or motor aphasia
- •visual field deficits
- •other neurological or systemic disorder which can cause dementia or cognitive dysfunction
- •intake of antidepressants, sedatives, or neuroleptics
Outcomes
Primary Outcomes
Accuracy of verticality perception
Time Frame: during the measurement period (10 minutes)
Secondary Outcomes
- Test-re-test reliability of verticality perception(from session 1 (day 0) to session 2 (day 1))