Distal Nerve Electrical Stimulation for Neuromuscular Reinnervation
- Conditions
- Electrical StimulationPeripheral Nerve Regeneration
- Registration Number
- NCT06687460
- Lead Sponsor
- National Cheng-Kung University Hospital
- Brief Summary
During the process of nerve microsurgical reconstruction, 30 minutes of electrical stimulation is applied to the distal end of the damaged nerve to assess its potential benefits for nerve regeneration, functional recovery, slowing down the degeneration at the neuromuscular junction, and preventing muscle atrophy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 21
- Adults aged 18 and older
- Acute peripheral nerve rupture between the elbow and wrist
- Acute rupture of the median or ulnar nerve
- Patients who have signed a valid written consent for surgery and trials
- History of injury or other causes leading to muscle and joint dysfunction in the affected area
- Patients with radial nerve damage
- Diabetes
- History of arrhythmia
- Stroke
- Multiple sclerosis
- Hereditary peripheral neuropathy
- Amyotrophic lateral sclerosis (ALS)
- Patients with a pacemaker
- Presence of local infection at the wound site
- Pregnant or breastfeeding women
- Patients deemed unsuitable for enrollment by a physician
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method NCV/EMG(CMAP,latency) The third month after surgery. The electromyography (EMG) is a diagnostic method used to assess muscle and nerve function, primarily to detect muscle activity and nerve conduction velocity, in order to monitor the recovery of neuromuscular function after surgery. During the EMG examination, the examiner uses electrodes attached to the palm to measure and record the electrophysiological signals of the muscles for further analysis. Through this method, doctors can evaluate the electrophysiological activity of the muscles to assess the reinnervation of distal muscles by the damaged nerves.
- Secondary Outcome Measures
Name Time Method DASH questionnaire The first, third, and sixth months after surgery. The DASH questionnaire (Disabilities of the Arm, Shoulder, and Hand) is a tool used to assess a patient's upper extremity function and symptoms. It helps in evaluating the impact of musculoskeletal disorders on daily activities and quality of life.
Muscle power The third and sixth months after surgery. Muscle power refers to the ability of a muscle or group of muscles to exert force quickly. It is a combination of strength and speed, and is often measured in activities that require explosive movements, such as sprinting, jumping, or lifting weights. Muscle power is important for athletic performance and functional movement in daily activities.
Purdue Pegboard test The third and sixth months after surgery. The Purdue Pegboard test is a standardized assessment used to measure manual dexterity and fine motor skills. It involves placing pegs into holes on a board as quickly and accurately as possible, using one hand at a time and then both hands. The test is commonly used in occupational therapy, rehabilitation, and research to evaluate hand function and coordination.
MMDT The third and sixth months after surgery Assessment of hand dexterity and posture tolerance
NCV/EMG(CMAP,latency) The sixth month after surgery. Electromyography (EMG) is a diagnostic method used to assess muscle and nerve function, primarily for detecting muscle activity and nerve conduction velocity to monitor the recovery of neuromuscular function post-surgery. During an EMG examination, the examiner attaches electrodes to the palm to measure and record the electrophysiological signals of the muscles for further analysis. This allows physicians to evaluate the electrophysiological activity of the muscles and assess the reinnervation of distal muscles by the damaged nerves.
Trial Locations
- Locations (1)
National Cheng Kung University Hospital
🇨🇳Tainan City, Taiwan