Prospective observational study to clarify the effect of pneumococcal vaccine in interstitial lung disease patients with immunosuppressive therapy
Not Applicable
- Conditions
- interstitial lung disease
- Registration Number
- JPRN-UMIN000015225
- Lead Sponsor
- Sapporo medical university Respiratory medicine and allergology
- Brief Summary
IgG concentrations to serotype 19F were increased in all groups in response to the vaccine. Both PCV13 and PPSV23 induced IgG concentrations in patients immunized for the first time. Response rates for the ILD group were comparable with those for the ILD group undergoing corticosteroid therapy. Only idiopathic pulmonary fibrosis patients undergoing immunosuppressive therapy had a significantly lower response.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who are vaccinated with pneumococcal vaccine within the last year
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We measure opsonic activity (OPA) and the rise of the antibody titer of the before and after vaccination. We compare antibody titers, the rise of OPA in the non-treatment group and the immunosuppressive therapy group.
- Secondary Outcome Measures
Name Time Method