NL-OMON51635
Recruiting
Phase 2
Prospective clinical trial to evaluate the efficacy of acetazolamide for the treatment of cystoid macular edema in inherited retinal dystrophies: the CAR trial - The CAR trial
Amsterdam UMC0 sites18 target enrollmentTBD
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Inherited retinal dystrophies
- Sponsor
- Amsterdam UMC
- Enrollment
- 18
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Eligible patients received a clinical diagnosis of IRD, and underwent at least
- •one clinical examination, in combination with one of the following
- •prerequisites:
- •IRD associated with causal genetic variant(s) (in e.g., USH2A, CRB1, RHO,
- •RP1, RP2, RPGR, PRPF31, or RS1 gene)
- •CME involving the fovea confirmed on spectral\-domain optical coherence
- •tomography (OCT)
Exclusion Criteria
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •Eyes will be excluded when the visual dysfunction is also significantly
- •associated with other ocular diseases besides the IRDs (e.g., glaucoma,
- •perforating trauma).
- •Patients treated with loop diuretics
- •Severe hepatic impairment
- •Severe renal insufficiency
- •Sodium and Potassium Depletion
- •Addison's disease
Outcomes
Primary Outcomes
Not specified
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