ooking for signs of inflammation in the brain of Chronic Fatigue Syndrome Patients
Recruiting
- Conditions
- Chronic Fatigue syndromeChronisch vermoeidheidssyndroom
- Registration Number
- NL-OMON27481
- Lead Sponsor
- niversity Medical Center Groningen9713 GZ Groningen, The Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Control subjects:
- Female, between 18 and 60 years old;
Exclusion Criteria
All subjects:
- Women who are pregnant;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary objective of this study is to evaluate whether there is an increased binding potential of the TSPO ligand [11C]PK11195, which is a marker for microglia activation in neuroinflammation, using PET in patients with chronic fatigue syndrome compared to Q-fever fatigue syndrome and healthy age- and sexe-matched controls.
- Secondary Outcome Measures
Name Time Method - To correlate the binding potential of [11C]PK11195 to MRI measurements in the same patients (for example grey matter reduction).<br /><br>- To correlate binding potential of [11C]PK11195 to fatigue severity using the CIS fatigue questionnaire.<br /><br>- To correlate binding potential of [11C]PK11195 expression to peripheral cytokine concentrations.<br>