Prospective randomised double blinded interventional study to compare the dose of ephedrine required to control hypotension in patients receiving two different doses of ondansetron during elective caesarean section under spinal anaesthesia :At SMS Medical College, Jaipur
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- 1)To determine the difference in total dose of ephedrine required to control hypotension between two different doses of intravenous ondansetron in parturients undergoing elective lower segment caesarean section .
研究概览
简要总结
The aim of this study is to compare the efficacy of two different dose of intravenous ondansetron in preventing the hypotension after spinal anaesthesia by calculating the total dose of ephedrine required to control hypotension in patients undergoing elective caesarean section. In this study two different doses of intravenous ondansetron 4mg and 8mg will be given 5 minutes before spinal anaesthesia . Total dose of ephedrine required to control hypotension will be calculated in both groups. This will help us to know the effective dose of ondansetron to prevent hypotension in LSCS cases under spinal anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- Female
入选标准
- •Patients undergoing elective caesarean section.
- •Age between 18-35 years.
- •Patients belonging to American Society Of Anaesthesiologist(ASA) grade II.
- •Patients consenting to participate.
排除标准
- •History of pre eclampsia and eclampsia.
- •Obesity 3)Patients with allergy to drugs used in the study.
- •Patients with contraindication to neuraxial anaesthesia.
- •Patients with history of drug abuse or addictions.
结局指标
主要结局
1)To determine the difference in total dose of ephedrine required to control hypotension between two different doses of intravenous ondansetron in parturients undergoing elective lower segment caesarean section .
时间窗: Baseline | 00 minutes(after spinal) | 01 minutes | 02 minutes | 03 minutes | 05 minutes | 10 minutes | 15 minutes | 20 minutes | 25 minutes | 30 minutes | 40 minutes | 50 minutes | 60 minutes
2)To determine the difference in proportion of hypotension between two different doses of intravenous ondansetron in parturients undergoing elective lower segment caesarean section.
时间窗: Baseline | 00 minutes(after spinal) | 01 minutes | 02 minutes | 03 minutes | 05 minutes | 10 minutes | 15 minutes | 20 minutes | 25 minutes | 30 minutes | 40 minutes | 50 minutes | 60 minutes
次要结局
- To determine side effects between both groups -Nausea, Vomiting, shivering, bradycardia(The application of spinal anaesthesia till completion of surgery.)