Measurement of MRP2 Function Using Urinary Coproporphyrins

Completed

• Conditions: Healthy Subjects

• Registration Number: NCT00746044
• Lead Sponsor: University Hospital, Tours

Brief Summary

Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control. Thus it would be very useful to get an easily measurable biomarker reflecting individual's MRP2 activity. We aimed to investigate the ratio of urinary coproporphyrins I and III (UCP(I/I+III), known to be increased in patients with mutations in MRP2/ABCC2 gene.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-02
• Primary Completion: 2008-04
• Study First Submitted: 2008-09-01
• Study First Submitted QC: 2008-09-01
• Study First Posted: 2008-09-03
• Study Completion: 2009-04
• Status Verified: 2009-05
• Last Update Submitted: 2009-05-14
• Last Update Posted: 2009-05-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Healthy
• > 18 y
• Affiliated to an health insurance

Exclusion Criteria

• Patient not able to understand or to comply to the protocol

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Urinary coproporphyrins (I/I+III)ratio	End of three 24-hours periods

Secondary Outcome Measures

Name	Time	Method
ABCC2 polymorphisms	At the time of entering in the study

Trial Locations

Locations (1)

CHRU de TOURS; 🇫🇷 Tours, France