Preimplantion Genetic Testing for Aneuploidies (PGT-A) in Patients With Recurrent Implantation Failure: a Pilot RCT

Universitaire Ziekenhuizen KU Leuven1 site in 1 country100 target enrollmentMay 1, 2019

ConditionsRecurrent Implantation Failure

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Recurrent Implantation Failure
Sponsor: Universitaire Ziekenhuizen KU Leuven
Enrollment: 100
Locations: 1
Primary Endpoint: OPR
Status: Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Assessing whether Preimplantation Genetic Testing for Aneuploidy (PGT-A) can increase the ongoing pregnancy rate per transferred embryo and can decrease the time to pregnancy and miscarriage rate in patients with Recurrent Implantation Failure (RIF)

Registry

clinicaltrials.gov

Start Date

May 1, 2019

End Date

December 31, 2026

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

Universitaire Ziekenhuizen KU Leuven

Responsible Party

Principal Investigator

Brecht Geysenbergh

Principal Investigator

Universitaire Ziekenhuizen KU Leuven

Eligibility Criteria

Inclusion Criteria

•Women with recurrent implantation failure (previous transfer of least 4 good quality embryos in at least 3 fresh or frozen cycles)
•BMI \< 35
•Normal hysteroscopy

Exclusion Criteria

•thin endometrium in previous cycles (\<6mm), endometriosis ASRM score III-IV, premature ovarian failure (POF, Bologna criteria), abnormal karyotype, donor oocytes or embryos, PGT-M