Preimplantation Genetic Testing for Aneuploidies in Patients With Recurrent Implantation Failure
Not Applicable
Recruiting
- Conditions
- Recurrent Implantation Failure
- Registration Number
- NCT03900780
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
Assessing whether Preimplantation Genetic Testing for Aneuploidy (PGT-A) can increase the ongoing pregnancy rate per transferred embryo and can decrease the time to pregnancy and miscarriage rate in patients with Recurrent Implantation Failure (RIF)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
- Women with recurrent implantation failure (previous transfer of least 4 good quality embryos in at least 3 fresh or frozen cycles)
- BMI < 35
- Normal hysteroscopy
Exclusion Criteria
- thin endometrium in previous cycles (<6mm), endometriosis ASRM score III-IV, premature ovarian failure (POF, Bologna criteria), abnormal karyotype, donor oocytes or embryos, PGT-M
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method OPR at 20 weeks gestational age Ongoing pregnancy rate per embryo transfer
- Secondary Outcome Measures
Name Time Method IR 2 weeks Implantation rate per transferred embryo
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie aneuploidy-related implantation failure in PGT-A trials?
How does PGT-A compare to standard embryo selection methods in RIF patients?
Which biomarkers are most predictive of successful embryo implantation post-PGT-A?
What adverse events are associated with PGT-A in recurrent implantation failure cases?
Are there combination therapies that enhance PGT-A outcomes in RIF patients?
Trial Locations
- Locations (1)
UZ Leuven
🇧🇪Leuven, Belgium
UZ Leuven🇧🇪Leuven, BelgiumMyriam WelkenhuysenContact+3216343544myriam.welkenhuysen@uzleuven.beBrecht Geysenbergh, MDContact+32496125137brecht.geysenbergh@uzleuven.be