Sympathetic Activity and Renal Denervation
- Conditions
- Hypertension
- Registration Number
- NCT01355055
- Lead Sponsor
- Hannover Medical School
- Brief Summary
Primary hypothesis:
Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension.
Secondary hypotheses:
1. The magnitude of the individual depressor response after catheter-based renal denervation depends on the extent of sympathoinhibition.
2. Both, the reduction in arterial pressure and in central sympathetic activation are sustained over time up to 24±3 months after catheter-based renal denervation.
3. Catheter-based renal denervation resets the sympathetic baroreflex to lower blood pressure values.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
- Refractory hypertension (as defined by the WHO: poorly controlled hypertension (>140/90 mmHg) despite adequate doses of at least three antihypertensive drugs including a diuretic)
- Men or women aged >18 years
- Intact peroneal nerve
- Written informed consent
Exclusion Criteria
- Diseases, dysfunctions, or medications (such as NET inhibitors) that exclude a participation in the study according to the investigator.
- Legal incompetence or circumstances that interfere with the patient´s ability to fully understand scope, relevance, and/or consequences of participation in this study.
- People in custody
- hypersensitivity to clonidine, phenylephrine, or nitroprusside-sodium
- sick sinus syndrome, second or third degree AV block, bradycardia < 50 bpm (contraindication for clonidine)
- endogenous depression (contraindication for clonidine)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hannover Medical School
🇩🇪Hannover, Germany