Influences of Catheter-based Renal Denervation on Central Sympathetic Nervous System Regulation in Refractory Hypertension

Hannover Medical School1 site in 1 country26 target enrollmentMarch 2011

Overview

Primary hypothesis:

Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension.

Secondary hypotheses:

The magnitude of the individual depressor response after catheter-based renal denervation depends on the extent of sympathoinhibition.
Both, the reduction in arterial pressure and in central sympathetic activation are sustained over time up to 24±3 months after catheter-based renal denervation.
Catheter-based renal denervation resets the sympathetic baroreflex to lower blood pressure values.

Registry

clinicaltrials.gov

Start Date

March 2011

End Date

TBD

Last Updated

14 years ago

Study Type

Observational

Sex

All

Sponsor

•Refractory hypertension (as defined by the WHO: poorly controlled hypertension (\>140/90 mmHg) despite adequate doses of at least three antihypertensive drugs including a diuretic)
•Men or women aged \>18 years
•Intact peroneal nerve
•Written informed consent

•Diseases, dysfunctions, or medications (such as NET inhibitors) that exclude a participation in the study according to the investigator.
•Legal incompetence or circumstances that interfere with the patient´s ability to fully understand scope, relevance, and/or consequences of participation in this study.
•People in custody
•hypersensitivity to clonidine, phenylephrine, or nitroprusside-sodium
•sick sinus syndrome, second or third degree AV block, bradycardia \< 50 bpm (contraindication for clonidine)
•endogenous depression (contraindication for clonidine)