Influences of Catheter-based Renal Denervation on Central Sympathetic Nervous System Regulation in Refractory Hypertension

Hannover Medical School1 个研究点分布在 1 个国家目标入组 26 人开始时间: 2011年3月最近更新: 2011年5月17日

适应症

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Primary hypothesis:

Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension.

Secondary hypotheses:

The magnitude of the individual depressor response after catheter-based renal denervation depends on the extent of sympathoinhibition.
Both, the reduction in arterial pressure and in central sympathetic activation are sustained over time up to 24±3 months after catheter-based renal denervation.
Catheter-based renal denervation resets the sympathetic baroreflex to lower blood pressure values.

•Refractory hypertension (as defined by the WHO: poorly controlled hypertension (>140/90 mmHg) despite adequate doses of at least three antihypertensive drugs including a diuretic)
•Men or women aged >18 years
•Intact peroneal nerve
•Written informed consent

•Diseases, dysfunctions, or medications (such as NET inhibitors) that exclude a participation in the study according to the investigator.
•Legal incompetence or circumstances that interfere with the patient´s ability to fully understand scope, relevance, and/or consequences of participation in this study.
•People in custody
•hypersensitivity to clonidine, phenylephrine, or nitroprusside-sodium
•sick sinus syndrome, second or third degree AV block, bradycardia < 50 bpm (contraindication for clonidine)
•endogenous depression (contraindication for clonidine)

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