Vascular Sensitivity to Adrenergic Agonists in Patients With CHF and in Healthy Subjects
- Conditions
- Congestive Heart Failure
- Registration Number
- NCT00782782
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
Congestive Heart failure (CHF) is asociated with changes in cardiac function and vascular responses. The aim of this study is to characterize these differences. Our hypothesis is, that there are differences in vascular responses between healthy subjects and patients with CHF.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Patients with congestive heart failure NYHA I-II
- Stable clinical condition
Exclusion Criteria
- Resting systolic blood pressure < 100
- Resting heart rate < 50
- Hypersensitivity to dexmedetomidine, phenylephrine, isoproterenol, terbutaline
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method vascular sensitivity (ED50) and response (Emax) to dexmedetomidine, phenylephrine, isoproterenol and terbutaline 3 weeks
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie adrenergic agonist-induced vascular resistance in CHF patients compared to healthy controls?
How do alpha- and beta-adrenergic receptor signaling pathways differ in vascular responses between CHF and healthy populations?
Which biomarkers correlate with differential vascular reactivity to adrenergic stimulation in CHF subtypes like systolic vs. diastolic dysfunction?
What adverse events are associated with adrenergic agonist testing in CHF populations and how are they managed?
How do alpha-adrenergic receptor modulators compare to beta-adrenergic agents in managing vascular dysfunction in CHF patients?
Trial Locations
- Locations (1)
Hadassah University Hospital
🇮🇱Jerusalem, Israel