Neuroimaging Studies of Smoking and Treatment
Not Applicable
Completed
- Conditions
- Smoking Cessation
- Registration Number
- NCT03085602
- Lead Sponsor
- University of Kansas Medical Center
- Brief Summary
The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
- smoke > 10 cigarettes per day
- vision is normal or corrected-to-normal
Exclusion Criteria
- serious medical illness unsuitable for the MR scanner based on best clinical judgment
- any neurologic or psychiatric disorder
- diabetes
- known heart disease
- high blood pressure
- currently taking psychotropic or cardiovascular medication
- history of alcohol or other substance dependence or current abuse
- risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc)
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in activation in reward processing regions of the brain Change from Baseline to Week 4
- Secondary Outcome Measures
Name Time Method Change in activation in cognitive control regions of the brain Change from Baseline to Week 4 Change in connectivity between reward and cognitive control regions of the brain Change from Baseline to Week 4
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie cognitive control improvements in NCT03085602 smoking cessation trial?
How does fMRI-based cognitive behavioral therapy compare to standard nicotine replacement therapies for smoking cessation?
Which biomarkers correlate with successful smoking cessation outcomes in behavioral intervention trials like NCT03085602?
What adverse events are associated with fMRI-monitored cognitive behavioral therapy for nicotine addiction?
Are there synergistic effects when combining fMRI-guided behavioral therapy with pharmacological agents like varenicline in smoking cessation?
Trial Locations
- Locations (1)
Hoglund Brain Imaging Center, University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Hoglund Brain Imaging Center, University of Kansas Medical Center🇺🇸Kansas City, Kansas, United States