Neuroimaging Studies of Smoking and Treatment

Not Applicable

Completed

• Conditions: Smoking Cessation
• Interventions: Behavioral: Cognitive behavioral therapy; Behavioral: Health education

• Registration Number: NCT03085602
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12
• Study First Submitted: 2017-03-15
• Study First Submitted QC: 2017-03-15
• Study First Posted: 2017-03-21
• Primary Completion: 2019-02-01
• Study Completion: 2019-02-01
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-12
• Last Update Posted: 2019-04-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

• smoke > 10 cigarettes per day
• vision is normal or corrected-to-normal

Exclusion Criteria

• serious medical illness unsuitable for the MR scanner based on best clinical judgment
• any neurologic or psychiatric disorder
• diabetes
• known heart disease
• high blood pressure
• currently taking psychotropic or cardiovascular medication
• history of alcohol or other substance dependence or current abuse
• risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc)
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CBT Treatment	Cognitive behavioral therapy	Participants receive Cognitive behavioral therapy (CBT). Participants will receive 4 one hour CBT treatments.
Control Group	Health education	Participants receive health education treatment. Participants will attend treatment sessions that match the CBT Treatment arm with respect to time and contact.

Primary Outcome Measures

Name	Time	Method
Change in activation in reward processing regions of the brain	Change from Baseline to Week 4

Secondary Outcome Measures

Name	Time	Method
Change in activation in cognitive control regions of the brain	Change from Baseline to Week 4
Change in connectivity between reward and cognitive control regions of the brain	Change from Baseline to Week 4

Trial Locations

Locations (1)

Hoglund Brain Imaging Center, University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States