Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia
- Conditions
- Hypoxia, Altitude
- Interventions
- Procedure: Hypoxia
- Registration Number
- NCT03823677
- Lead Sponsor
- Universitätsklinikum Köln
- Brief Summary
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
- Detailed Description
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 250
- Helathy
- Ear problems
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description hypoxia 5000ft group 30 Hypoxia Intervention: 30 minutes hypoxia hypoxia 5000ft group 15 Hypoxia Intervention: 15 minutes hypoxia hypoxia 8000ft group 30 Hypoxia Intervention: 30 minutes hypoxia hypoxia 15000ft group 60 Hypoxia Intervention: 60 minutes hypoxia hypoxia 5000ft group 60 Hypoxia Intervention: 60 minutes hypoxia hypoxia 10000ft group 30 Hypoxia Intervention: 30 minutes hypoxia hypoxia 8000ft group 15 Hypoxia Intervention: 15 minutes hypoxia hypoxia 10000ft group 15 Hypoxia Intervention: 15 minutes hypoxia hypoxia 15000ft group 30 Hypoxia Intervention: 30 minutes hypoxia hypoxia 8000ft group 60 Hypoxia Intervention: 60 minutes hypoxia hypoxia 10000ft group 60 Hypoxia Intervention: 60 minutes hypoxia hypoxia 15000ft group 15 Hypoxia Intervention: 15 minutes hypoxia
- Primary Outcome Measures
Name Time Method Protein Expression before hypoxia Measurement immediately 1 minute before of hypoxia/experiment proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Emotional assessment tears Measurement starts immediately with hypoxia in the pressure chamber. duration 10 minutes Emotional tears test
Emotional assessment Measurement in the pressure chamber after tears test (i.e. 10 minutes after start). duration 10 minutes Emotional stroop test; Williams, J. M. G., Mathews, A., \& MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120, 3-24.
Protein Expression after hypoxia Measurement immediately and at termination (i.e., 1 minute after) of hypoxia/experiment proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Emotional assessment mood Measurement in the pressure chamber after stroop test (i.e. 20 minutes after start). duration 10 minutes Emotional mood test, POMS mood score. Shukitt-Hale, B., Banderet, L.E., \& Lieberman, H.R. (1998). Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia, The International Journal of Aviation Psychology, 8, 319-334,
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital of Cologne
🇩🇪Cologne, NRW, Germany