Alcohol Diet and Drug Use Preceding Alcoholic Hepatitis
- Conditions
- Hepatitis, Alcoholic
- Registration Number
- NCT02404636
- Lead Sponsor
- University Hospital Birmingham
- Brief Summary
ADDUP is an observational study of patients with alcoholic hepatitis. A structured interview is used to quantitatively estimate:
1. Alcohol use
2. Dietary intake
3. Drug use (legal and illegal)
in the weeks preceding onset of acute alcoholic hepatitis. After interview patients are followed up for 12 months with regard to response to therapy and survival.
The study is intended to explore potential precipitants of alcoholic hepatitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- acute alcoholic hepatitis
- aged over 18 years
- able to give informed consent
Exclusion Criteria
- evidence of other acute or chronic liver disease
- episode of alcoholic hepatitis in 6 months before admission
- severe hepatic encephalopathy
- delirium
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in alcohol intake, dietary intake or drug use before illness 1 month Behavior before admission (Brief structured interview)
- Secondary Outcome Measures
Name Time Method Response to treatment (Brief structured interview) 1 week Response to treatment (corticosteroids, pentoxifylline or supportive medical care) after 1 week, measured by Lille score
Survival after admission (Brief structured interview) 12 months Survival
Trial Locations
- Locations (1)
Queen Elizabeth Hospital Birmingham
🇬🇧Birmingham, West Midlands, United Kingdom
Queen Elizabeth Hospital Birmingham🇬🇧Birmingham, West Midlands, United Kingdom