The effects of gamma tACS on cortical excitability and movement in Parkinson patients compared to healthy controls

Not Applicable

Recruiting

• Conditions: G20; G20.1; Parkinson disease

• Registration Number: DRKS00024035
• Lead Sponsor: Carl von Ossietzky Universität Oldenburg Fakultät VI - Medizin und Gesundheitswissenschaften Department für Humanmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Parkinson Patients:
a) diagnosed PD in a mild to moderate stage, equivalent UPDRS (part III) < 35
b) Right-handedness
c) Age 50 -75 years
d) Fluency in German or English.

Healthy Subjects are recruited based on : b), c) and d)

Exclusion Criteria

For healthy subjects and PD patients:
a) Implanted neurostimulators, cochlear implants or general implanted metal in the cranium
b) Psychiatric disorders (i.e. schizophrenia, severe dementia)
c) Epilepsy
d) Use of contraindicated medication (i.e. neuroleptics, opioids)
e) Coffee or alcohol consumption prior to the experiment

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The endpoint is the improvement of motor function after gamma tACS. Improve motor function will be assessed by the UPDRS, and changes in results in the Nine-hole- peg test and alternating finger tapping task.

Secondary Outcome Measures

Name	Time	Method
The secondary endpoint is the change in reaction time after the execution of a motor task in the course of the experiment.