24-hour Urinary Electrolyte Excretion in Chronic Kidney Disease

Completed

• Conditions: Chronic Kidney Diseases; Electrolyte Imbalance

• Registration Number: NCT05550467
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

Association between excretion pattern and development trajectory of urinary electrolytes (urine sodium, urine potassium, urine chlorine, urine magnesium, urine calcium, urine phosphorus, urine creatinine, urea, uric acid, urine glucose, urine protein, urine retinol) and adverse prognosis in patients with chronic kidney disease

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-01
• Primary Completion: 2022-07-30
• Study Completion: 2022-07-31
• Status Verified: 2022-09
• Study First Submitted: 2022-09-19
• Study First Submitted QC: 2022-09-19
• Last Update Submitted: 2022-09-19
• Study First Posted: 2022-09-22
• Last Update Posted: 2022-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

• Our study is a retrospective cohort study. The study included patients with adult（Age≥18years）CKD who were hospitalized in the Department of Nephrology, First Medical Center of Chinese PLA General Hospital from January 2014 to July 2022. Patients with CKD who had one or more 24-hour urinary electrolyte excretion tests at intervals of more than three months were included in the subgroup analysis.

Exclusion Criteria

• Patients with hemodialysis therapy and urine volume less than 500ml were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Death	2014.1.1-2022.7.31	All cause death
Kidney disease progression	2014.1.1-2022.7.31	eGFR decline \> 50%; dialysis; kidney transplant

Secondary Outcome Measures

Name	Time	Method
Cardiovascular disease	2014.1.1-2022.7.31	myocardial infarction, angina pectoris, stable heart failure, peripheral artery disease , revascularization, cerebrovascular events