Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency): Pilot Study.
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Score social responsiveness scale
研究概览
简要总结
There is currently no treatment for the body symptoms of Autism Spectrum Disorders (ASD). However, basic research suggests that some forms of ASD may be alleviated, even in the adult stage. The genes involved in ASDs particularly impact synaptic homeostasis. Specific clinical trials in patients with synaptic mutations need to be carried out. In this spirit, patients with deleterious mutations in SHANK3 represent a paradigm. The induced pluripotent stem cells (iPSc) carrying SHANK3 mutations and derived in neurons, can be used for high-throughput screening of pharmacological substances and allow the identification of compounds that can restore the expression level of SHANK3. The objective of this proposed project is to test one of the compounds identified by research on these iPSc as a novel treatment for social communication deficit in patients with deleterious mutations in SHANK3. Its effect on the symptoms of the social deficit could represent a new perspective for other forms of idiopathic autism.
详细描述
Phase IIa intervention study, pilot, prospective, multicenter, randomized in 2 parallel arms, Li+ versus placebo, double-blind. The main objective of the study is to evaluate the effect of Li+ at 12 weeks, compared to placebo, on the social communication deficit in patients with Phelan-McDermid Syndrome (SHANK3 haploinsufficiency).
The Secondary Objectives are :
- To evaluate the effect of Li+ at 12 weeks on all cardinal and main symptoms in patients suffering from Phelan-McDemid Syndrome (PMS).
- Evaluate the tolerance of Li + for 12 weeks in children suffering from PMS.
- Demonstrate the feasibility of a phase III, randomized controlled trial.
- Evaluate the residual effect of treatment at 16 to 18 weeks after stopping treatment)
- Evaluate the parents' feelings at the end of the study regarding the child's behavior and the impact on their daily lives
The treatment of the study is lithium carbonate: Li+ carbonate capsules are prepared from the raw material for pharmaceutical use .
Inclusion will be ensured by the clinical genetics centers. Psychiatric evaluation will be carried out by the investigative child psychiatry service.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 7 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children under 18 years of age
- •Minimum weight of 20 kg for children aged 7 years old
- •Patient with haplo deficiency SHANK3, i.e. carrier of a SHANK3 deletion (CNV) or a de novo truncating mutation in SHANK3 (Phelan McDermid syndrome);
- •Total Social Responsiveness Scale - T score (SRS) of at least 66
- •Patients of childbearing age who are sexually active must agree to use a highly effective form of contraception (estrogen-progestin or progestin-only contraception, or an intrauterine device, or contraceptive abstinence).
- •Affiliation to a social security system
- •Signature of the consent by the holders of parental authority
- •Non-participation in another clinical trial
- •Diagnosis of Autism Spectrum Disorders (DSM-5 criteria) confirmed by Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Scale (ADOS-II)
- •IQ Assessment
- •Beta-HCG negative
排除标准
- •Hepatic or renal insufficiency (disturbed liver function tests, abnormal creatinine clearance);
- •Unbalanced thyroid or diabetic pathology;
- •Cardiac pathology: Brugada syndrome or family history of Brugada syndrome, heart failure;
- •Addison's disease;
- •Unstable epileptic disease.
- •Patient with concomitant diseases judged for which the experimental treatment with Li + could compromise tolerance ;
- •History of allergy to Li+;
- •Allergy to lactose, lactose being the sole diluent and excipient of the prepared form.
- •Initiation of co-occurring cognitive-behavioural therapy that is specifically focused on autistic symptoms within 6 weeks prior to inclusion;
- •Any introduction of psychotropic drugs within 2 weeks prior to trial, including neuroleptics, monoamine oxidase inhibitors, stimulants, antidepressants. For neuroleptic drugs and Fluoxetine, this delay should be 4 weeks prior to the trial;
- •Serious behavioural problems or refusal to take medication that does not allow for compliance;
- •Inability to perform blood tests to check lithemia when the patient is included.
研究组 & 干预措施
Lithium
Li+ is an FDA (NDA: 016834) and ANSM (AMM 3400931376339) approved drug. There are two lithium salts that are marketed in France, Teralithe LI (cp 250mg) and Teralithe LP (cp 400mg).
The experimental drugs in this study will be lithium carbonate capsules dosed at 62.5mg, 125mg and 250mg prepared as hospital preparations for clinical trials.
干预措施: Lithium Carbonate (Drug)
Placebo
Capsules containing lactose monohydrate in all points resembling the capsules of active ingredients.
Capsules of pla62.5 mg, pla125 mg and pla250 mg (pla=placebo)
干预措施: Placebo (Drug)
结局指标
主要结局
Score social responsiveness scale
时间窗: 12 weeks
Severity of Autistic Symptoms - Social Responsiveness Scale - Total score at 12 weeks.
次要结局
- Score social responsiveness scale(Baseline (At randomization) , 4 weeks, 8 weeks, and 16 to 18 weeks after stopping the treatment)
- score of child's sleep disorder rating scale(Baseline (At randomization) , 4 weeks, 8 weeks, 12 weeks and 16 to 18 weeks after stopping the treatment)
- Score of Dunn Sensory Profile(4 weeks, 8 weeks, 12 weeks and 16 to 18 weeks after stopping the treatment)
- score of autism diagnosis observation scale(Baseline (At randomization) and 12 weeks)
- Score of attention deficit hyperactivity disorder(Baseline (At randomization) 4 weeks, 8 weeks, 12 weeks, and 16 to 18 weeks after stopping the treatment)
- Score of Aberrant Behavior checklist scale(Baseline (At randomization), 4 weeks, 8 weeks and 12 weeks)
- score of global functioning(Baseline (At randomization), 4 weeks, 8 weeks, 12 weeks and 16 to 18 weeks after stopping the treatment)
- Score of surrounding constraints(Baseline (At randomization), 4 weeks, 8 weeks, 12 weeks and 16 to 18 weeks after stopping the treatment)
- Score of Vineland Adaptive Behavior Composite(Baseline (At randomization) and12 weeks)
- score of Columbia Suicide Severity Rating Scale(Baseline (At randomization)and 12 weeks)