Minimally invasive, Indocyanine-Guided Metastasectomy in patients with Colorectal Liver Metastases
Recruiting
- Conditions
- Colorectal liver metastases
- Registration Number
- NL-OMON21326
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 186
Inclusion Criteria
18 years or older
Patients with colorectal liver metastases (primary and recurrent CRLM) planned for curative-intent minimally invasive surgery, either laparoscopic or robotic resection
Patients eligible for indocyanine infusion 24h prior to surgery according to the hospitals protocol
Patients with or without neoadjuvant chemotherapy (for primary and/or secondary colorectal tumor/metastases)
Exclusion Criteria
Patients with contraindications for Indocyanine green:
o Iodide allergy of allergies for shells and/or clamps
o Impaired kidney function (eGRF <50)
Local recurrent CRLM at the site of previous ablative therapy
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage radical resections
- Secondary Outcome Measures
Name Time Method Incremental diagnostic accuracy of NIRF imaging<br>The impact of fluorescent guided resections on surgical patient parameters (eg. Blood loss, operation time)<br>The short-term (<6 months) oncological outcomes and intrahepatic recurrence rates, with an emphasis on local recurrence at the site of resection. These outcomes will be compared with the Dutch Hepato Biliary Audit (DHBA) data.<br>Long-term oncological outcomes: overall survival, disease free survival