Comparative analysis of Injectable platelet rich fibrin (i-PRF) and Microneedling (MN) for gingival augmentation in thin gingival biotype patients: A randomized clinical trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Increase in gingival thickness and keratinized tissue width will be measured after interventions
研究概览
简要总结
Gingiva is the part of the oral mucosa that surrounds the necks of the teeth and covers the alveolar processes of the jaws . The gingival biotype has been used to describe the thickness of the gingiva in the faciopalatal dimension. and it is a genetically determined trait.
Characteristics of thin gingival biotype - Highly scalloped gingival tissue usually may present with slight gingival recession, Delicate and thin periodontium, Tissue appears friable with a minimal zone of attached gingiva.
The response of thin gingival biotype to various stimuli or conditions can differ from that of thicker biotypes. Here are some considerations regarding the tissue response to thin gingival biotype: Increased susceptibility to recession due to trauma from various factors such as toothbrushing, periodontal procedures, or orthodontic treatment. Thin gingival tissues may have a reduced blood supply compared to thicker tissues. This can impair the tissue’s ability to heal and resist infection.
Thin gingival biotype be converted or enhanced into thick biotype by following procedures i.e. The use of connective tissue grafts, Acellular dermal matrix , Use of platelet-rich fibrin (PRF) membrane etc.
Purpose of the study- Due to the positive effects of i-PRF and microneddling on the biological potential, neoangiogenesis, neocollagenesis and wound-healing because of various cells and growth factors i.e. white blood cells, platelets, transforming growth factor-β and collagen-1 mRNA, platelet-derived growth factors, connective tissue growth factor and fibroblast growth factors .
In light of these factors, this study will evaluate the effects of standalone i-prf and microneedling on gingival thickness and keratinized tissue width in individuals with thin gingival biotypes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •(1) Patients with age ≥18 years (2) Patients with Gingival thickness of the mandibular anterior teeth ≤1.5mm (Seibert and Lindhe-1989).14 (3) Patients with no malocclusion, crowding, fillings, missing or supernumerary mandibular anterior teeth.
- •(4) Systemically healthy patients.
- •(5) Non-smoker patients.
- •(6) Patients who will give an informed consent.
排除标准
- •(1) Patients with active orthodontic treatment.
- •(2) Patients with history of previous periodontal surgery in last 6 months.
- •(3) Patients with any systemic disease affecting periodontal health.
- •(4) Patients currently using blood thinners.
- •(5) Patients using any drugs that might lead to gingival enlargement.
- •(6) Pregnant ladies or lactating mothers.
结局指标
主要结局
Increase in gingival thickness and keratinized tissue width will be measured after interventions
时间窗: increased gingival thickness and keratinized tissue width will be measured at 1 month 3 month 6 month
次要结局
- Secondary outcomes in this trial are Plaque index Gingival index Pocket depth Clinical attachment level(All above mentioned parameters will be measured at baseline 1 month 3 month 6 month)
研究者
Masood Kamal
King georges medical university