Study of Gene Associations and Infertility

• Conditions: Infertility

• Registration Number: NCT01223092
• Lead Sponsor: Reproductive Medicine Associates of New Jersey

Brief Summary

The purpose of this this study is to use DNA screening strategies to identify genes and localize genomic regions that are differentially expressed in patients with infertility to further understand the genetic basis for reproductive competence.

Detailed Description

Experimental strategies seek to discover small variants in DNA sequences, which are associated with certain infertility parameters. The alleles being analyzed in in vitro fertilization (IVF) population are sought to be associated with functional differences in the expression of the gene product that are then mechanistically linked to infertility.

Study Timeline

• Study Start: 2006-02
• Study First Submitted: 2010-10-08
• Study First Submitted QC: 2010-10-15
• Study First Posted: 2010-10-18
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-04
• Last Update Posted: 2025-02-07
• Primary Completion: 2025-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• all patients undergoing fertility care

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of retrieved oocytes	1 month

Secondary Outcome Measures

Name	Time	Method
Fertilization rate	1 month	Number of oocytes that are fertilized
Pregnancy rates	1 year	Clinical pregnancy rates (detection of pregnancy hormone bHCG in blood) and delivery rates.
Number of available embryos	1 month	Number of embryos that are available for transfer on day 3 or day 5

Trial Locations

Locations (1)

Reproductive Medicine Associates of New Jersey; 🇺🇸 Basking Ridge, New Jersey, United States