The Role of Neuroimaging assisted Functional and structural connectomics in cognitive rehabilitation following traumatic brain injury in relation to Neurological outcomes, Lobar functioning and Emotional Recognition- A prospective longitudinal study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1. Correlation between neuropsychological assessment scores and neuroimaging results
研究概览
简要总结
The study aims to explore the relationship between neuroimaging assisted brain connectivity patterns and cognitive recovery in Traumatic Brain Injury (TBI) patients, with a focus on cognitive rehabilitation outcomes. By utilizing advanced structural and functional neuroimaging techniques, the research observes the correlation of neuropsychological scores with the neuroimaging results over three time points. The study examines the recovery cognitive functions such as attention, memory, visuospatial cognition, visual perception and emotional recognition. The study aims to explore how cognitive rehabilitation improves brain plasticity, promotes recovery and improvement in TBI patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •age- 18-65 years both male and female patients who had sustained a brain injury with the GCS score of 4-15.
排除标准
- •Other pre-existing neurological disorders or prior head injury Patients with Impaired vision Haemodynamic instability that persists for more than 7 days after injury Clinical evidence of brainstem dysfunction within 7 days of admission conditions contraindicative of MRI such as implants.
结局指标
主要结局
1. Correlation between neuropsychological assessment scores and neuroimaging results
时间窗: Measured at Baseline (T1), 3 months (T2), and 6 months (T3)
2. Relationship between structural and functional connectivity
时间窗: Measured at Baseline (T1), 3 months (T2), and 6 months (T3)
3. Improvements in cognitive functioning post cognitive rehabilitation
时间窗: Measured at Baseline (T1), 3 months (T2), and 6 months (T3)
4. Evidence of neuroplasticity observed through changes in brain connectivity
时间窗: Measured at Baseline (T1), 3 months (T2), and 6 months (T3)
次要结局
- 1. Resting state network activations correlated with specific cognitive domains(2. Recovery patterns based on TBI severity)
研究者
Madhumathi P C
Sri Ramachandra Institute of Higher Education and Research