Diffusion Weighted Magnetic Resonance Imaging of Brain in Monochorionic Twin Pregnancies With Demise of One Fetus

Completed

• Conditions: Twin Pregnancy With Antenatal Problem
• Interventions: Other: No intervention.

• Registration Number: NCT04966039
• Lead Sponsor: Peking University Third Hospital

Brief Summary

Diffusion weighted imaging (DWI) can reflect the microstructure and pathological changes of tissue, and diffusion tensor imaging (DTI) can quantitatively evaluate the fine structure of white matter in brain. In this study, conventional and diffusion-weighted MRI (DWI, DTI) sequences were used to analyze the brain of monochorionic twin pregnancies with demise of one fetus.

Detailed Description

With the incidence rate of twin pregnancy increasing, the incidence of intrauterine death of twin pregnancies is also rising, which has great impact on the morbidity and mortality of the other fetus, and increases the mortality of fetal survival, premature birth, brain damage and long-term sequela. Therefore, it is necessary to examine the central nervous system of the surviving fetus of twin pregnancy and intrauterine death. When the surviving fetus is complicated with nervous system abnormalities, conventional MRI can generally make a diagnosis. However, some of the surviving fetuses may not find other structural or echo abnormalities on B-mode ultrasonography, and even these fetuses do not find structural or signal abnormalities on routine MRI examination. Whether the surviving fetuses may have brain abnormalities cannot be detected early by the above methods. Diffusion weighted imaging (DWI) can reflect the microstructure and pathological changes of tissue, and diffusion tensor imaging (DTI) can quantitatively evaluate the fine structure of white matter in brain.

The present study is to use conventional sequence and diffusion-weighted imaging (DWI, DTI) to analyze the brain of monochorionic twin pregnancies with demise of one fetus, which aims to find the potential brain abnormalities early and provide some guidance for the clinical diagnosis and treatment in the next step.

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-06
• Study First Submitted: 2021-06-29
• Study First Submitted QC: 2021-07-14
• Last Update Submitted: 2021-07-14
• Study First Posted: 2021-07-19
• Last Update Posted: 2021-07-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

1. Twin pregnancy was diagnosed and one fetus died in utero
2. Twin pregnancy with one abnormal fetus
3. Singleton pregnancy with abnormalities outside the fetal brain

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Exclusion Criteria

1. Those who can't cooperate with MRI examination, such as those who have metal, claustrophobia or can't insist on scanning.
2. Pregnant women with gestational age less than 20 weeks.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Singleton control group	No intervention.	Singleton pregnancy with abnormalities outside the fetal brain, 20 pregnant women
Twin control group	No intervention.	Twin pregnancy with one abnormal fetus, 20 pregnant women
monochorionic twin pregnancies with demise of one fetus	No intervention.	Twin pregnancy was diagnosed and one fetus died in utero, 20 pregnant women

Primary Outcome Measures

Name	Time	Method
MRI	baseline	conventional sequence
basic information	baseline	intrauterine death time of one fetus

Trial Locations

Locations (1)

Peking University Third Hospital; 🇨🇳 Beijing, China