Stress and retrieval of heroin-related memories in abstinent heroin addicts

Not Applicable

Completed

• Conditions: Heroin addiction; Mental and Behavioural Disorders; Mental and behavioural disorders due to use of opioids

• Registration Number: ISRCTN48521078
• Lead Sponsor: The National Basic Research Program of China (973 Program) (China)

Brief Summary

2010 results in: https://www.ncbi.nlm.nih.gov/pubmed/19890257 (added 04/07/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2008-08-30
• Study Start: 2009-01-23
• Last Update Posted: 29 July 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 102

Inclusion Criteria

1. Aged from 20 to 40 years, male only
2. Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria for heroin dependence with opiate free for at least one month
3. No use of other drugs

Exclusion Criteria

1. Current use of any medications
2. Current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder
3. Current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria)
4. Risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal infections, hyperlipidaemia, history of hypertension, or abnormal electrocardiogram [ECG] or other laboratory findings)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effect of propranolol and cortisol administration on heroin-related memory retrieval in abstinent heroin addicts, measured 1 hour after the medicine treatment.

Secondary Outcome Measures

Name	Time	Method
The effect of propranolol and cortisol on salivary cortisol levels 1 hour after drug administration.