ISRCTN53688797CompletedNot Applicable
Quantitative assessment of myocardial perfusion with magnetic resonance using an intravascular contrast agent: an open label trial
King's College London (UK)0 sites156 target enrollmentStarted: November 13, 2009Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 156
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Known coronary artery disease (with or without prior percutaneous revascularisation)
- •2. Indication for percutaneous coronary intervention (PCI)
- •3. The subject is 18 years of age or older, either sex
- •4. The subject is conscious and able to comply with study procedures
- •5. Written informed consent has been obtained
Exclusion Criteria
- •1. Contraindications for magnetic resonance imaging (MRI)
- •2. Contraindications to gadolinium-based contrast agents (known allergies or a contra-indication to gadolinium (Gd) chelates or renal insufficiency)
- •3. Contraindications to adenosine stress:
- •3.1. Myocardial infarction less than 3 days
- •3.2. Unstable angina pectoris
- •3.3. Severe arterial hypertension
- •3.4. Asthma or severe obstructive pulmonary disease requiring treatment (chronic obstructive pulmonary disease [COPD])
- •3.5. Sick sinus syndrome or a symptomatic bradycardia, atrioventricular (AV) block greater than IIa, trifascicular block
- •3.6. Allergy against vasodilator
- •3.7. Allergy against gadolinium-based contrast agents or renal insufficiency
- •3.8. Other contraindications for adenosine or dipyridamole administration
- •4. The subject has significant cardiac arrhythmia (i.e. atrial fibrillation)
- •5. Pregnancy
- •6. Heart failure (New York Heart Association [NYHA] grade IV)
- •7. The subject's electrocardiogram (ECG) shows prolonged QT interval
- •8. Severe arterial hypotension (less than 90 mmHg systolic)
- •9. Claustrophobia
Investigators
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