临床试验/NCT01027546

NCT01027546已完成不适用

Effect of Tranexamic Acid on Reducing Postoperative Blood Loss in Cervical Laminoplasty

Yodakubo Hospital0 个研究点目标入组 40 人开始时间: 2007年1月最近更新: 2009年12月8日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 40
主要终点: perioperative blood loss

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者记录与标识符相似试验

研究概览

简要总结

The purpose is to evaluate the efficacy of tranexamic acid in cervical laminoplasty; the surgical procedure used was identical in all cases.

详细描述

Tranexamic acid, an inhibitor of fibrinolysis, has proven to be effective in reducing perioperative blood loss in patients undergoing total hip and knee arthroplasty. However, limited numbers of well-controlled trials in spinal surgery have been conducted due to heterogeneity in the performed surgical procedures.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Single (Participant)

入排标准

性别: All
接受健康志愿者: 否

入选标准

•Patients who were scheduled to undergo cervical laminoplasty from C3 to C6 for cervical multilevel compressive myelopathy with a narrow spinal canal for which nonoperative therapy had failed.

排除标准

•Patients with chronic renal failure, cirrhosis of the liver, serious cardiac disease, allergy to TXA, a history of thromboembolic disease, and bleeding disorders, as well as those who were currently receiving antiplatelet and/or anticoagulant drugs, were excluded from this study.

研究组 & 干预措施

placebo, tranexamic acid

Placebo Comparator

干预措施: Tranexamic Acid (Drug)

结局指标

主要结局

perioperative blood loss

时间窗: during and after surgery

次要结局

未报告次要终点

研究者

发起方

Yodakubo Hospital

申办方类型

Other

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