The Development of Advanced Reading Skills: Normalization and Compensation Effects among Children with a Familial Risk of Dyslexia - an fMRI study

Completed

Conditions: Dyslexie
specific reading disability
wordblindness

Registration Number: NL-OMON40707

Lead Sponsor: Rijksuniversiteit Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 43

Inclusion Criteria

- Children who have participated in EEG study (METc 2012/076)
- Parental informed consent for participation
- Child*s informed consent for participation
- Agreeing that any abnormal findings with medical consequences will be communicated to the parents and the child*s general practitioner

Exclusion Criteria

- Uncorrected abnormal vision
- Hearing problems
- Brain damage as a result of head trauma or a medical condition
- Serious health or psychiatric problems as reported by the parents
- MR-related exclusion criteria:
o Presence of metal implants (including some non-removable braces)
o Presence of electronic implants (e.g., heart pacemakers) and connectors of electronic
devices (e.g., implanted electrodes)
o (possible) pregnancy
o claustrophobia

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Performance (speed and accuracy) on behavioural tests investigating among<br /><br>others: second language reading comprehension, text reading, word reading,<br /><br>vocabulary, spelling and phonemic awareness.<br /><br>- Patterns of blood-oxygen level dependent (BOLD) activation related to the<br /><br>different language tasks that participants will execute while being scanned,<br /><br>compared between groups (control group, at-risk group without dyslexia, at-risk<br /><br>group with dyslexia), taking performance on the tasks into account.<br /><br>- Patterns of brain structural connectivity (localized fractional anisotropy<br /><br>(FA)) as obtained from DTI.</p><br>

Secondary Outcome Measures