Effect of Maternal Multiple Micronutrient Supplementation From Preconception Through Lactation on Child Growth and Development in Rural Pakistan: A Follow-up Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- University of Toronto
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Full scale IQ score
- Status
- Completed
- Last Updated
- 8 months ago
Overview
Brief Summary
The goal of this observational study is to learn about the long-term effects of maternal multiple micronutrient supplementation from preconception through to lactation on child neurodevelopment and growth in a resource-limited setting where there is a high burden of malnutrition. The main questions it aims to answer are:
- Does maternal multiple micronutrient supplementation from preconception through to lactation compared to the standard of care have an effect on child neurodevelopment?
- Does maternal multiple micronutrient supplementation from preconception through to lactation compared to the standard of care have an effect on child growth?
This is a cross-sectional follow up study to a substudy of breastmilk composition and infant growth within the Matiari emPowerment and Preconception Supplementation (MaPPS) Trial, wherein mothers were randomized to receive a multiple micronutrient supplement from preconception through to lactation or the standard of care (ClinicalTrials.gov Identifier: NCT04451395).
Investigators
Deborah O'Connor
Chair, Department of Nutritional Sciences
University of Toronto
Eligibility Criteria
Inclusion Criteria
- •Child participated in the MaPPS Trial Breastmilk Sub-study at 3-months of age
- •Child has reached their fourth birthday
- •Child is available in the study catchment area (Matiari District)
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Full scale IQ score
Time Frame: At 4 years of age
Wechsler Preschool and Primary Scale of Intelligence (WPPSI), minimum score: 40 and maximum score: 160 (higher scores mean a better outcome)
Secondary Outcomes
- Fine and gross motor skills score(At 4 years of age)
- Height(At 4 years of age)
- Head circumference(At 4 years of age)