Effect of zinc in treatment of depressio
Phase 3
- Conditions
- Major Depression Disorder.
- Registration Number
- IRCT20150706023084N2
- Lead Sponsor
- Islamic Azad University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
Diagnosis of major depressive disorder by a psychiatrist based on DSM-IV-TR
Patients aged between 18 and 55 years old
Obtaining informed consent from the patients
No supplements usage at least four weeks before the study
Not taking any medication except for those associated with depression status
Patients whose Beck test shows moderate to high depression
Exclusion Criteria
Pregnancy or lactation
Severe psychotic symptoms
Changing drug class
Symptoms requiring hospitalization including suicidal thoughts and actions
Any disease that changes the level of Homovanillic acid levels, such as thyroid disease and drug addiction
Neurological diseases, Pheochromocytoma, Panic disorder, and PTSD and any internal diseases
Smoking
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hemovalenic acid is one of the essential metabolites of catecholamines and is the result of the action of the enriched COMT and MAO on them. Three parts of body fluids can be local to measure HVA. These fluids include CSF, urine and plasma. Since more than 90% of the HVA produced in the brain, without appearing in the CSF, directly enters the bloodstream, and blood samples (as compared to CSF) can easily be collected. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: The serum HVA level was measured by the DYNEX DSX and the HVA kit of the Zelbio Company, prepared by ELISA, was used to calculate the antibody response.;Beck Depression Inventory. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: Beck questionnaire.
- Secondary Outcome Measures
Name Time Method Mean serum levels of homovanillic acid. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: The serum HVA level was measured by the DYNEX DSX and the HBA kit of the Zelbio Company, prepared by ELISA, was used to calculate the antibody response.;The number obtained from Beck's questionnaire. Timepoint: At the beginning of the study, the patient was examined and at the end of the study (after 12 weeks). Method of measurement: Beck questionnaire.