Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Heart rate
研究概览
简要总结
Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy
详细描述
Direct laryngoscopy and intubation are painful stimulus that activates sympathoadrenal discharge which results in intense cardiovascular reflex i.e. tachycardia and hypertension. In this study we will compare effects of intravenous dexmedetomidine, fentanyl and lidocaine for attenuation of these reflexes in patient undergoing laproscopic cholecystectomy. how these agents will effect hemodynamic response during pneumoperitoneum. Tertiary objective will be to observe sedation, perioperative complications and recovery in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
盲法说明
Patients do not know about the interventions.
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA-I and ll patients
- •Male and female patient of age 20-70 years.
- •Undergoing Elective surgery
- •Intubation by skilled anesthetist of at least 2 years' experience
- •Intubation not more than 45 seconds
排除标准
- •Patients with uncontrolled DM, HTN, IHD, endocrine or autonomic dysfunction
- •Pregnant and lactating females
- •Short thick neck with anticipated difficult intubation
- •Any sort of obstructive restrictive or reactive airway disease
- •Patient allergic to any of the study medications.
- •Obese patients, Narcotic addicts
研究组 & 干预措施
Dexmedetomidine
Group A patients receive intravenous dexmedetomidine 0.06mg/kg in 100ml normal saline 0.9% over 10minutes.
干预措施: dexmedetomidine (Drug)
Fentanyl
Group B receives intravenous fentanyl at 2mcg/kg in 100ml saline over 10 minutes in induction room.
干预措施: fentanyl (Drug)
Lidocaine
Group C patients receives intravenous lidocaine 1.5mg/kg in 100ml saline over 10 minutes in induction room.
干预措施: lidocaine (Drug)
结局指标
主要结局
Heart rate
时间窗: at induction
Hemodynamic responses (average heart rate beats a minute)
systolic blood pressure
时间窗: at induction
hermodynamic response (Top number will be assessed of blood pressure)
mean atrial pressure
时间窗: at induction
Hemodynamic responses (average blood pressure in an individual during a single cardiac cycle)
Oxygen saturation (SpO2)
时间窗: at induction
Hemodynamic responses) (arterial oxy-hemoglobin saturation is measured non-invasively by a finger pulse oximeter or handheld pulse oximeter,
Diastolic blood pressure
时间窗: at induction
hermodynamic response (bottom number will be assessed of blood pressure)
次要结局
- Recovery assessment(at 10 minutes post operatively)
- Sedation assessment(at 10 minutes post operative)
- Complications(1 week Post-operative(Operation -discharge))
研究者
Sana Urooj
SUrooj
Dow University of Health Sciences