Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

Medical University of Graz1 site in 1 country60 target enrollmentDecember 23, 2020

ConditionsPulmonary Hypertension Kidney Transplantation Haemodialysis

Overview

Phase: N/A
Intervention: Not specified
Conditions: Pulmonary Hypertension
Sponsor: Medical University of Graz
Enrollment: 60
Locations: 1
Primary Endpoint: Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope
Status: Active, Not Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.

Registry

clinicaltrials.gov

Start Date

December 23, 2020

End Date

December 31, 2027

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

Medical University of Graz

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age: ≥ 18 years
•patients listed for first kidney transplantation at the Clinical Division of Nephrology

Exclusion Criteria

•Age \< 18 years
•combined organ transplantations (heart-kidney, pancreas-kidney etc.)
•patients with prior kidney transplantation
•high calcium score on cardiac-CT (\> 160 Agatston Score)

Outcomes

Primary Outcomes

Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope

Time Frame: Baseline and 1 year after kidney transplantation

Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography

Secondary Outcomes

Change in pulmonary vascular resistance at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
Change in systolic pulmonary arterial pressure at rest before versus one year after kidney transplantation assessed by (exercise) echocardiography(Baseline and 1 year after kidney transplantation)
Change in pulmonary vascular resistance during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
Change in systolic pulmonary arterial pressure at 25 Watts before versus one year after kidney transplantation assessed by (exercise) echocardiography(Baseline and 1 year after kidney transplantation)
Change in mean pulmonary arterial pressure at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
Change in mean pulmonary arterial pressure during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
Change in cardiac output during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
Change in pulmonary arterial wedge pressure at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
Change in cardiac output at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
Change in pulmonary arterial wedge pressure during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)