NCT04842591进行中（未招募）不适用
Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation
Medical University of Graz1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2020年12月23日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope
研究概览
简要总结
The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: ≥ 18 years
- •patients listed for first kidney transplantation at the Clinical Division of Nephrology
排除标准
- •Age < 18 years
- •combined organ transplantations (heart-kidney, pancreas-kidney etc.)
- •patients with prior kidney transplantation
- •high calcium score on cardiac-CT (> 160 Agatston Score)
结局指标
主要结局
Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope
时间窗: Baseline and 1 year after kidney transplantation
Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography
次要结局
- Change in pulmonary vascular resistance at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
- Change in systolic pulmonary arterial pressure at rest before versus one year after kidney transplantation assessed by (exercise) echocardiography(Baseline and 1 year after kidney transplantation)
- Change in pulmonary vascular resistance during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
- Change in systolic pulmonary arterial pressure at 25 Watts before versus one year after kidney transplantation assessed by (exercise) echocardiography(Baseline and 1 year after kidney transplantation)
- Change in mean pulmonary arterial pressure at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
- Change in mean pulmonary arterial pressure during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
- Change in cardiac output during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
- Change in pulmonary arterial wedge pressure at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
- Change in cardiac output at rest before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
- Change in pulmonary arterial wedge pressure during exercise before versus one year after kidney transplantation(Baseline and 1 year after kidney transplantation)
研究者
研究点 (1)
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