Pulmonary Hemodynamics During Exercise - Research Network
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Pulmonary Circulation Diseases
- Sponsor
- Medical University of Graz
- Enrollment
- 1500
- Locations
- 32
- Primary Endpoint
- Number of Participants who die during observation
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
- •Written informed consent of participating subjects after being fully briefed (for prospective analysis)
Exclusion Criteria
- •Patients with incomplete hemodynamic data at rest or exercise
- •Patients without sufficient follow-up data (information on survival / lung transplantation)
- •advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
- •advanced heart failure with pulmonary arterial wedge pressure (PAWP) \> 18 mmHg at rest
- •uncontrolled systemic arterial hypertension (RR values \> 160/100 mmHg at rest)
- •FEV1\<50% predicted
- •TLC\<60% predicted
Outcomes
Primary Outcomes
Number of Participants who die during observation
Time Frame: 6 years
The investigators aim to assess the prognostic relevance of pulmonary hemodynamics during exercise as assessed by right heart catheterization by using a multi-centre approach and to identify independent predictors of adverse events. Separate data sets will be analysed for the retrospective and prospective Evaluation.
Number of Participants undergoing lung Transplantation during observation
Time Frame: 6 years
Occurrences of lung transplantations
Secondary Outcomes
- Number of Participants being hospitalized during observation(6 years)
- Number of Participants who develop pulmonary Hypertension as assessed by right heart catheterization(6 years)
- Number of Participants with newly initiated pulmonary arterial Hypertension medication during observation(6 years)