Comparative clinical and radiographic evaluation of efficacy of demineralized bone matrix versus demineralized freeze dried bone allograft in treatment of infrabony defects: a randomized controlled clinical trial
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Plaque index (PI), Gingival index (GI), Probing pocket depth (PD), Relative attachment level (RAL)
Study Overview
Brief Summary
The study will be done to evaluate clinical & radiographic efficacy of Demineralized Bone Matrix in comparison of that of Demineralized Freeze Dried Bone Allograft in treatment of infrabony defects. It will be a randomized controlled clinical trial. Total treatment sites will be 30 with chronic periodontitis. After 3-4 weeks of scaling, patients will be called for surgical procedure. After incision, reflection and degranulation; the infrabony defects will be filled with either Demineralized Bone Matrix or Demineralized Freeze Dried Bone Allograft according to the inclusion groups. The flaps will be sutured with 4 0 silk sutures. Plaque index, gingival index, pocket probing depth and clinical attachment level will be recorded preoperatively and postoperatively. Radiographs will be taken preoperatively and postoperatively.
Study Design
- Study Type
- Interventional
- Allocation
- Coin toss, Lottery, toss of dice, shuffling cards etc
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 25.00 Year(s) to 70.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients of both sexes having no systemic conditions that would contraindicate routine periodontal procedures.
- •Age More than or equal to 25 years of age, with no history of any periodontal surgery in the past 1 year.
- •The sites having radiographic evidence of angular bone loss More than or equal to 3 mm deep and probing depth of More than or equal to 5 mm.
Exclusion Criteria
- •Participants who had received periodontal flap/regenerative therapy within the past 1 year.
- •Patients with deleterious oral habits such as smoking, tobacco chewing.
- •Pregnant and Lactating mothers.
- •Patients who were on antibiotic and nonsteroidal anti-inflammatory drugs within the past 1 year.
Outcomes
Primary Outcomes
Plaque index (PI), Gingival index (GI), Probing pocket depth (PD), Relative attachment level (RAL)
Time Frame: At baseline, 1 month and 6 months
Secondary Outcomes
- Radiographic evaluation(Baseline)