Comparative clinical and radiographic evaluation of efficacy of demineralized bone matrix versus demineralized freeze dried bone allograft in treatment of apical location of the base of the pocket relative to the bone crest: a randomized controlled clinical trial

Phase 4

Completed

• Conditions: Chronic periodontitis,

• Registration Number: CTRI/2023/07/055895
• Lead Sponsor: Dr Rishabh Trivedi

Brief Summary

The study will be done to evaluate clinical & radiographic efficacy of Demineralized Bone Matrix in comparison of that of Demineralized Freeze Dried Bone Allograft in treatment of infrabony defects. It will be a randomized controlled clinical trial. Total treatment sites will be 30 with chronic periodontitis. After 3-4 weeks of scaling, patients will be called for surgical procedure. After incision, reflection and degranulation; the infrabony defects will be filled with either Demineralized Bone Matrix or Demineralized Freeze Dried Bone Allograft according to the inclusion groups. The flaps will be sutured with 4 0 silk sutures. Plaque index, gingival index, pocket probing depth and clinical attachment level will be recorded preoperatively and postoperatively. Radiographs will be taken preoperatively and postoperatively.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-08
• Last Update Posted: 2024-02-04

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients of both sexes having no systemic conditions that would contraindicate routine periodontal procedures.
• Age More than or equal to 25 years of age, with no history of any periodontal surgery in the past 1 year.
• The sites having radiographic evidence of angular bone loss More than or equal to 3 mm deep and probing depth of More than or equal to 5 mm.

Exclusion Criteria

• Participants who had received periodontal flap/regenerative therapy within the past 1 year.
• Patients with deleterious oral habits such as smoking, tobacco chewing.
• Pregnant and Lactating mothers.
• Patients who were on antibiotic and nonsteroidal anti-inflammatory drugs within the past 1 year.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plaque index (PI), Gingival index (GI), Probing pocket depth (PD), Relative attachment level (RAL)	At baseline, 1 month and 6 months

Secondary Outcome Measures

Name	Time	Method
Radiographic evaluation	Baseline

Trial Locations

Locations (1)

Government Dental College and Hospital; 🇮🇳 Jamnagar, GUJARAT, India

Government Dental College and Hospital

🇮🇳Jamnagar, GUJARAT, India

Dr Rishabh Trivedi

Principal investigator

7600554887

rishabhtrivedi169@gmail.com