Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation

Not Applicable

Not yet recruiting

• Conditions: Alveolar Bone Loss
• Interventions: Procedure: Demineralized Dentin Allograft; Procedure: Demineralized Dentin Autograft

• Registration Number: NCT06457373
• Lead Sponsor: Horus University

Brief Summary

This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-06-03
• Study First Submitted QC: 2024-06-07
• Study First Posted: 2024-06-13
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-14
• Last Update Posted: 2025-04-15
• Study Start: 2025-08-01
• Primary Completion: 2026-08-01
• Study Completion: 2026-09-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Patients aged between 25 to 35 years old.
2. Patients scored as (ASA I).
3. No adverse habits such as smoking, tobacco chewing, alcohol.
4. Patients having bilaterally impacted mandibular third molar with similar degree of difficulty according to (Kim JY, et al).
5. The recipient alveolar sockets are free of any pre-existing periapical pathology, based on x-ray.
6. Alveolar sockets with a depth of 5 mm or more, using periodontal probe for assessment.
7. Patients sign a consent for all procedures.

Exclusion Criteria

• 1. Pregnant or lactating patients. 2) Relevant systemic diseases. 3) Patients with history of chemotherapy or radiotherapy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A	Demineralized Dentin Allograft	20 sockets will be grafted with Demineralized Dentin Allograft (DDA)
Group B	Demineralized Dentin Autograft	20 sockets will be grafted with Demineralized Dentin Autograft (Auto-DD)

Primary Outcome Measures

Name	Time	Method
Measuring and comparing the width of bone between the two groups	Immediately post-operative, 3months post-operative, 6months post-operative	We will measure the width of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation
Measuring and comparing the height of bone between the two groups	Immediately post-operative, 3months post-operative, 6months post-operative	We will measure the height of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation

Secondary Outcome Measures

Name	Time	Method
Assess and comparing the pain of both groups	One day post-operative, one week post-operative	we will use the Visual Analogue Scale (VAS) for pain measurement
Assess and comparing the soft tissue parameters (bleeding on probing and color of the gingiva) of both groups	One day post-operative, one week post-operative	The bleeding on probing will be assessed by using periodontal probe and this will be done around mandibular first and second molars
Assess and comparing the swelling of both groups	One day post-operative, one week post-operative	Swelling levels after surgery will be measured using anatomic landmarks (Tragus-Labial commissure and Tragus-Pogonion), the distances between the landmarks used for the evaluation methods will be measured before the operation.; All measurements will be done using millimeter ruler, while the patient will be seated.
Assess and comparing the mouth opening of both groups	One day post-operative, one week post-operative	Assess the mouth opening of the patient using a millimeter ruler (by measuring the distance between maxillary incisal edge and mandibular incisal edge) and comparing the results of both groups

Trial Locations

Locations (1)

Faculty of Dentistry- Horus University in Egypt; 🇪🇬 Damietta, New-Damietta, Egypt