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Clinical Trials/NCT06609720
NCT06609720
Completed
Not Applicable

Evaluation of Autogenous Dentin Graft Versus Demineralized Freeze-Dried Bone Allograft in the Treatment of Class ΙΙ and ΙΙΙ Mandibular Furcation Defects

Tanta University1 site in 1 country32 target enrollmentMarch 1, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Autogenous Dentin Graft
Sponsor
Tanta University
Enrollment
32
Locations
1
Primary Endpoint
Probing pocket depth
Status
Completed
Last Updated
last year

Overview

Brief Summary

Randomized clinical and radiographic trial

Detailed Description

Evaluation of Autogenous Dentin Graft versus Demineralized Freeze-Dried Bone Allograft in the Treatment of Class ΙΙ and ΙΙΙ Mandibular Furcation Defects

Registry
clinicaltrials.gov
Start Date
March 1, 2021
End Date
December 30, 2023
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Banan Lotfy Mohamed Amer

Assistant lecturer at periodontology department, Principal Investigator, MSC

Tanta University

Eligibility Criteria

Inclusion Criteria

  • Presence of class II and/or ΙΙΙ furcation defects in mandibular first or second molars according to criteria outlined by Hamp et. al.
  • Horizontal probing depth ≥3 mm using Naber's probe.
  • Clinical attachment level ≥3 mm measured from cemento-enamel junction (CEJ) till the deepest probing depth.
  • Evidence of radiolucency in the furcation area on panoramic radiograph.
  • Patients who will be assigned for groups (I and II) should present with teeth required for extraction due to advanced periodontal bone loss or other indications such as hopeless wisdom teeth or orthodontic indications or unrestorable fractured teeth as a source for autogenous dentin graft (ADG).

Exclusion Criteria

  • Medically compromised patients and systemic conditions precluding periodontal surgery.
  • Mandibular first or second molars with root caries or endodontic treatment.
  • Smokers, diabetics, pregnant or lactating women.
  • History of chemotherapy, radiotherapy in head and/or neck region.
  • Bisphosphonate therapy.

Outcomes

Primary Outcomes

Probing pocket depth

Time Frame: Measured at baseline, 6 months and 12 months

According to Ramfjord, clinical parameter measured by UNC periodontal probe from a fixed point to the deepest probing depth. Using stent to standardize the measurements.

Clinical attachment level

Time Frame: Measured at baseline, 6 months and 12 months

According to Ramfjord, clinical parameter measured by a Naber\'s probe. Using stent to standard measurements.

Bleeding on probing

Time Frame: Measured at baseline, 6 months and 12 months

According to Ramfjord, the bleeding at each site observed after probing and recorded positive if bleeding was observed within 30 seconds, if not was recorded as negative.

Secondary Outcomes

  • Radiographic outcome(measured at baseline and 1 year follow up)

Study Sites (1)

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