Tooth Graft of Two Different Particle Sizes in Extraction Sockets

Not Applicable

• Conditions: Socket Preservation
• Interventions: Device: Dentin grinder; Device: Bone mill

• Registration Number: NCT04377178
• Lead Sponsor: SVS Institute of Dental Sciences

Brief Summary

The primary objective of the present study is to clinically and radiographically evaluate the efficacy of autogenous tooth graft obtained from bone mill and dental grinder to preserve alveolar ridge dimensions in extraction sockets.

Detailed Description

Accordingly, teeth will be used as a test material to allow for comparative tests after processing it in the automated milling system (AMS). The material will be moistened and then placed in toto into the extraction sockets to generate particles at settings 1 (500 RPM for 30s) or 2 (900 RPM for 30s) to generate MS and SS respectively ((SS group; 0.5-0.8 mm) and medium size (MS group; 1.0-1.2 mm)).

Study Timeline

• Study Start: 2019-05-25
• Study First Submitted: 2020-04-29
• Status Verified: 2020-05
• Study First Submitted QC: 2020-05-02
• Last Update Submitted: 2020-05-02
• Study First Posted: 2020-05-06
• Last Update Posted: 2020-05-06
• Primary Completion: 2020-09-25
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Systemically healthy individuals within the age group of 20-50 years with presence of teeth with hopeless prognosis requiring extraction

Exclusion Criteria

• Medically compromised patients.
• Subjects who underwent radiotherapy or chemotherapy in the past 12 months.
• Patients having uncontrolled periodontal disease or having an active sinus infection.
• Smokers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dentin chips group from automated mill	Dentin grinder	Dentin particles prepared from dentin grinder will be placed in extraction socket immediately after extraction
Manually milled Dentin chips	Bone mill	Dentin particles prepared from bone mill will be placed in extraction socket immediately after extraction.

Primary Outcome Measures

Name	Time	Method
Bone density	Baseline to 6months	Radiographs will be taken with digitalized RVG machine (DX 3000, DEXCOWN portable dental X-ray system) at 60Kvp/2Ma with inactive interface. RVG images taken at baseline and 6 months will be utilized to evaluate bone mineral density through Hounsfield units (HU).
Bone fill	Baseline to 6months	The radiograph obtained at 3 and 6 months will be subtracted from the radiograph taken at the baseline by using commercially available image processing software (Adobe Photoshop® 6.0, Adobe Systems, San Jose, USA). After digital subtraction, the digitized and excluded residual bone height will be transferred to open source software for area calculation (ImageJ®, Research Services Branch, NIH, Bethesda, Maryland, USA) for area calculation. The area of the layer will be calculated (in mm2) by initially enclosing the entire area with the rectangular selection tool and then by using Analyze\>Analyze Particles tool.

Trial Locations

Locations (2)

R V Chandra; 🇮🇳 Hyderabad, Telangana, India

Svs Institute of Dental Sciences; 🇮🇳 Hyderabad, Telangana, India