Clinical and Radiographic Assessment of Autogenous Dentin Nanoparticles in Treatment of Stage III Periodontitis: A Split-Mouth Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Clinical attachment level
研究概览
简要总结
The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.
详细描述
In this study, the investigators tested the effect of demineralized autogenous dentine as a bone graft in treatment of stage III periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and bone gain in defect sites.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 16 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with good systemic health and no contraindication for periodontal surgery.
- •Patients who are able to maintain good oral hygiene.
- •Gingival thickness for the site selected should be ≥1mm.
- •Probing depth of ≥ 6mm.
- •Patient has at least one hopeless teeth
排除标准
- •Active infectious diseases (hepatitis, tubercu¬losis, HIV, etc....).
- •Medically compromised patients.
- •Smokers and alcoholic abusers
- •People who suffer from any systemic disease that affect the periodontium.
- •Pregnant, postmenopausal women.
- •People who take anti-inflammatory drugs, anti¬biotics or vitamins within the previous 3 month.
- •People who use mouth washes regularly
- •Participants in other clinical trials.
结局指标
主要结局
Clinical attachment level
时间窗: 6 months
Clinical attachment level was measured at baseline and 6 months
Bone gain
时间窗: 6 months
The bone gain is calculated by: * Preoperative VBL (at baseline): measured as the distance from cementoenamel junction (CEJ) to the base of the bone defect. * Postoperative VBL (after 6 months) measured as the distance from cementoenamel junction (CEJ) to the base of the bone formation. * Postoperative bone fill (bone gain after 6 months) \[measured by subtracting the preoperative VBL from the postoperative VBL\].
Vertical bone loss
时间窗: 6 months
vertical bone loss was measured from cementoenamel junction (CEJ) to the base of the bone defect in each site in group I \& II.
Probing pocket depth
时间窗: 6 months
Probing pocket depth was measured at baseline and 6 months
次要结局
- Plaque Index(6 months)
- Gingival index(6 months)
研究者
Enas Elgendy
Professor of Periodontology
October 6 University