Effect of Vitis Vinifera Extract on Oxidative Stress, Inflammatory Biomarkers and Hormones in High Trained Subjects After Resting and Intensive Physical Activity.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- Evaluate the changes of oxidative stress, microcirculation parameters, inflammation biomarkers and plasma adipokines in vitis vinifera extract supplemented and placebo subject before and after high intense training
研究概览
简要总结
There is evidence that intense physical activity has a potential effect on thrombotic events due to catecholamine release. The hormones leptin and adiponectin have been used as markers of cardiovascular risk, but they are few and contradictory studies that relate physical training intensity and duration of high plasma concentrations of these hormones. The use of antioxidants, such as proanthocyanidins present in grapes, may help in reducing the undesirable effects of intense training.
详细描述
Fifty four Brazilian healthy military without hyperglycemia, diabetes mellitus and endocrine disease were enrolled in this study. All subjects were high physically military trained. The Ethical Committee of the Universidade do Estado do Rio de Janeiro in Brazil (COEP008/2011) approved the study protocol. Informed consent was obtained from each subject after explanation of purpose and risks of all procedures used.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy physically active men
排除标准
- •Diabetes, hypertension, obesity subjects, drug use
研究组 & 干预措施
Dietary Supplement
Before the exercise, the individuals intake only one capsule with 205 mg of the grape fruit extract in capsule with 205 mg.
干预措施: grape fruit (vitis vinifera) extract in capsule with 205 mg (Dietary Supplement)
结局指标
主要结局
Evaluate the changes of oxidative stress, microcirculation parameters, inflammation biomarkers and plasma adipokines in vitis vinifera extract supplemented and placebo subject before and after high intense training
时间窗: This study will last 24 months (2013-2015)
次要结局
- Differences between oxidative stress biomarkers in vitis vinifera extract supplemented and placebo subject before and after high intense training(This study will last 24 months (2013-2015))
- Differences between adipokines in vitis vinifera extract supplemented and placebo subject before and after high intense training(This study will last 24 months (2013-2015))
- Differences between inflammation biomarkers in vitis vinifera extract supplemented and placebo subject before and after high intense training(This study will last 24 months (2013-2015))
- Differences between body composition and microcirculation parameters in vitis vinifera extract supplemented and placebo subject before and after high intense training(This study will last 24 months (2013-2015))
研究者
Josely Correa Koury
PhD
Rio de Janeiro State University