Rituximab Plus Lenalidomide for Patients With Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma (Follicular Lymphoma and Marginal Zone Lymphoma)
- Conditions
- Lymphoma, Non-Hodgkin
- Interventions
- Registration Number
- NCT01938001
- Lead Sponsor
- Celgene
- Brief Summary
This double-blind randomized, parallel group study will evaluate the efficacy and safety of lenalidomide (Revlimid, CC-5013) in combination with rituximab (MabThera/Rituxan) in patients with relapsed or refractory follicular lymphoma or marginal zone lymphoma. Patients will be randomized to receive either lenalidomide or placebo for twelve 28-day cycles in combination with rituximab. Anticipated time on study treatment is 1 year.
- Detailed Description
Indolent lymphoma is a slow growing but incurable lymphoma which includes follicular lymphoma and marginal zone lymphoma. Follicular lymphoma and marginal zone lymphoma are cancers of the B lymphocyte, a type of white blood cell. Lenalidomide is an immunomodulatory drug (a drug that affects the immune system) which alters the body's immune system and it may also interfere with the development of tiny blood vessels involved in tumor growth. Therefore, lenalidomide may reduce or prevent the growth of cancer cells. Lenalidomide has also been shown to restore the immune cells' ability to attack and kill tumor cells, an ability that may be inhibited by follicular lymphoma and other lymphomas. The combination of rituximab and lenalidomide may eliminate the cancer while restoring the immune system's ability to attack tumor cells.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 358
- Age ≥18 years at the time of signing the informed consent document.
- Understand and voluntarily sign an informed consent document prior to any study related assessments/procedures are conducted.
- Histologically confirmed marginal zone lymphoma or follicular lymphoma (grade 1, 2 or 3a; CD20+ by flow cytometry or histochemistry).
- Previously treated with at least one prior systemic chemotherapy, immunotherapy or chemoimmunotherapy and have received at least 2 previous doses of rituximab.
- Documented relapsed, refractory or progressive disease after treatment with systemic therapy and must not be rituximab-refractory.
- Investigator considers rituximab monotherapy appropriate.
- Bi-dimensionally measurable disease on cross sectional imaging by X-ray computed tomography (CT) or magnetic resonance imaging (MRI).
- Need of treatment for relapsed, progressed or refractory disease as assessed by the investigator.
- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
- Adequate bone marrow function.
- Willingness to follow study visit schedule, pregnancy precautions and other protocol requirements.
- Histology other than follicular or marginal zone lymphoma or clinical evidence of transformation or Grade 3b follicular lymphoma.
- Subjects taking corticosteroids during the last week prior to study treatment, unless administered at a dose equivalent to < 20 mg/day prednisone or prednisolone.
- Systemic anti-lymphoma therapy within 28 days or use of antibody agents within 8 weeks use of radioimmunotherapy within 6 months.
- Known seropositive for or active viral infection with hepatitis B virus (HBV) or/and human immunodeficiency virus (HIV).
- Known hepatitis C virus (HCV) positive with chronic HCV or active viral infection with HCV hepatitis requiring anti-viral medication (at time of randomization).
- Life expectancy < 6 months.
- Known sensitivity or allergy to murine products.
- Prior history of malignancies, other than follicular or marginal zone lymphoma, unless the subject has been free of the disease for ≥ 5 years.
- Prior use of lenalidomide.
- Known allergy to thalidomide.
- Neuropathy > Grade 1.
- Presence or history of central nervous system involvement by lymphoma.
- Subjects who are at a risk for a thromboembolic event and are not willing to take prophylaxis for it.
- Uncontrolled intercurrent illness.
- Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent document.
- Pregnant or lactating females.
- Any condition that places the subject at unacceptable risk if he/she were to participate in the study or that confounds the ability to interpret data from the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Rituximab and Placebo Placebo Participants received riituximab 375 mg/m\^2 IV every week in Cycle 1 (Days 1, 8, 15 and 22) and on Day 1 of every 28-day cycle from cycle 2 to 5 plus placebo (identically matched capsule) once daily on Days 1 to 21 of every 28-day cycle up, to 12 cycles. Rituximab and Lenalidomide Rituximab Participants received rituximab 375 mg/m\^2 intravenously (IV) every week in Cycle 1 (Days 1, 8, 15 and 22) and on Day 1 of every 28-day cycle from Cycles 2 to 5 plus lenalidomide 20 mg by mouth (PO) once daily on Days 1 to 21 every 28 days, up to 12 cycles (21-day treatment and 7-day rest period); if creatinine clearance (CrCl) was ≥ 30 mL/min but \< 60 mL/min, participants received lenalidomide 10 mg capsules on days 1 to 21 every 28 days. Rituximab and Placebo Rituximab Participants received riituximab 375 mg/m\^2 IV every week in Cycle 1 (Days 1, 8, 15 and 22) and on Day 1 of every 28-day cycle from cycle 2 to 5 plus placebo (identically matched capsule) once daily on Days 1 to 21 of every 28-day cycle up, to 12 cycles. Rituximab and Lenalidomide Lenalidomide Participants received rituximab 375 mg/m\^2 intravenously (IV) every week in Cycle 1 (Days 1, 8, 15 and 22) and on Day 1 of every 28-day cycle from Cycles 2 to 5 plus lenalidomide 20 mg by mouth (PO) once daily on Days 1 to 21 every 28 days, up to 12 cycles (21-day treatment and 7-day rest period); if creatinine clearance (CrCl) was ≥ 30 mL/min but \< 60 mL/min, participants received lenalidomide 10 mg capsules on days 1 to 21 every 28 days.
- Primary Outcome Measures
Name Time Method Kaplan Meier Estimate of Progression Free Survival Assessed by the Independent Review Committee (IRC) According to the 2007 International Working Group Response Criteria (IWGRC) From randomization of study drug up to disease progression or death, which occurred first; up to the data cut-off date of 22 June 2018; overall median follow-up time for all participants was 28.30 months (range: 0.1 to 51.3 months). Progression-free survival (PFS) was defined as the time from date of randomization into the study to the first observation of documented disease progression or death due to any cause, whichever occurred first. PFS was based on the data from the IRC review using the modified 2007 International Working Group Response Criteria (IWGRC) using FDA censoring rules.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With an Objective Response as Assessed by the IRC According to the 2007 IWGRC From date of first dose to data cut-off date of 22 June 2018; the median treatment duration was 11.19 months in the rituximab/lenalidomide arm and 11.04 months in the rituximab/placebo arm Percentage of participants with an objective response is defined as having a response of at least a PR during the study without administration of new anti-lymphoma therapy. A complete response = a complete disappearance of all detectable clinical and radiographic evidence of disease, disappearance of any disease-related symptoms, and normalization of biochemical abnormalities; a partial response (PR) = 50% decrease in SPD of the 6 largest dominant nodes or nodal masses. No increase in the size of other nodes, liver, or spleen. Splenic and hepatic nodules must regress by at least 50% in the SPD.
Durable Complete Response Rate (DCCR) as Assessed by the IRC According to the 2007 IWGRC From first dose of investigational product (IP) to data cut-off date of 22 June 2018; the median treatment duration was 11.19 months in the rituximab/lenalidomiade arm and 11.04 months in the rituximab/placebo arm DCCR was defined as the percentage of participants with a best response of complete response (CR) that lasted no less than one year (≥ 48 weeks) during the study prior to administration of new anti-lymphoma therapy. A CR is defined as a complete disappearance of any disease-related symptoms and normalization of biochemical abnormalities.
Percentage of Participants With a Best Response of Complete Response as Assessed by the IRC According to the 2007 IWGRC From date of first dose up to data cut-off date of 22 June 2018; the median treatment duration was 11.19 months in the rituximab/lenalidomide arm and 11.04 months in the rituximab/placebo arm Percentage of participants with a best response of at CR during the study without administration of new anti-lymphoma therapy. A CR = Complete disappearance of all detectable clinical and radiographic evidence of disease, disappearance of any disease-related symptoms, and normalization of biochemical abnormalities.
Kaplan-Meier Estimate of Duration of Complete Response (DOCR) as Assessed by the IRC According to the 2007 IWGRC From randomization up to data cut-off date of 22 June 2018; overall median follow-up time for all participants was 28.30 months (range: 0.1 to 51.3 months). DOCR was defined as the time from initial CR until documented PD or death. Participants who had not progressed at the time of analysis were censored at the last assessment date that the participant was known to be progression free. Participants who received a new treatment without documented progression were censored at the last assessment date that the participants was known to be progression free.
Kaplan-Meier Estimate of Overall Survival (OS) From date of randomization to death due to any cause (Average of 55.71 months and a maximum up to 95.2 months) Overall survival was defined as the time from randomization to death from any cause. Overall survival was censored at the last date that the participant was known to be alive for participants who were alive at the time of analysis and for participants who were lost to follow-up before death was documented.
Kaplan-Meier Estimate of Duration of Objective Response as Assessed by the IRC According to the 2007 IWGRC From randomization up to data cut-off date of 22 June 2018; overall median follow-up time for all participants was 28.30 months (range: 0.1 to 51.3 months). Duration of response (DOR) was defined as the time from initial response (at least PR) until documented progressive disease (PD) or death. Participants who had not progressed at the time of analysis were censored at the last assessment date that the participant was known to be progression free. Participants who received a new treatment without documented progression were censored at the last assessment date that the participants was known to be progression free.
Kaplan Meier Estimate of Event Free Survival as Assessed by the IRC According to the 2007 IWGRC From date of randomization to data cut-off date of 22 June 2018; overall median follow-up time for all participants was 28.30 months (range: 0.1 to 51.3 months). Event-free survival (EFS) was defined as the time from date of randomization to date of first documented progression, relapse, institution of new anti-lymphoma treatment (chemotherapy, radiotherapy or immunotherapy) or death from any cause. Responding participants and those who were lost to follow up were censored at their last tumor assessment date.
Kaplan Meier Estimate of Time to Next Anti-Lymphoma Treatment (TTNLT) From date of randomization to date of first documented administration of a new anti-lymphoma treatment (Average of 55.71 months and a maximum up to 95.2 months) Time to next anti-lymphoma treatment (TTNLT) was defined as the time from date of randomization to date of first documented administration of a new anti-lymphoma treatment (including chemotherapy, radiotherapy, radioimmunotherapy or immunotherapy). The time to the next anti-lymphoma treatment was of special interest to the study.
Number of Participants With Treatment Emergent Adverse Events (TEAEs) From first dose to 28 days post last dose (Average of 55.71 months and a maximum up to 95.2 months) TEAEs include AEs that started or worsened between the date of the first dose and 28 days after the date of the last dose. A serious adverse event (SAE) is any: • Death; • Life-threatening event; • Any inpatient hospitalization or prolongation of existing hospitalization; • Persistent or significant disability or incapacity; • Congenital anomaly or birth defect; • Any other important medical event. The investigator determined the relationship of an AE to study drug based on the timing of the AE relative to drug administration and whether or not other drugs, therapeutic interventions, or underlying conditions could provide a sufficient explanation for the event. The severity of an AE was evaluated by the investigator according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) (Version 4.03) where Grade 1 = Mild, Grade 2 = Moderate, Grade 3 = Severe, Grade 4 = Life-threatening and Grade 5 = Death
Trial Locations
- Locations (160)
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States
Arlington Cancer Center
🇺🇸Arlington, Texas, United States
Beijing Cancer Hospital
🇨🇳Beijing, PR, China
Xijing Hospital
🇨🇳Xi'an, China
Fundação Antonio Prudente - AC Camargo Câncer center
🇧🇷São Paulo, Brazil
CH Perpignan - Hopital Saint-Jean
🇫🇷Perpignan, France
Centre Hospitalier de Valence
🇫🇷Valence, France
Local Institution - 371
🇧🇪Gent, Belgium
Fujian Medical University Union Hospital
🇨🇳Fuzhou, China
Local Institution - 604
🇨🇳Hangzhou City, China
Northwest Medical Specialties PLLC
🇺🇸Tacoma, Washington, United States
Real e Benemerita Associacao Portuguesa de Beneficencia
🇧🇷São Paulo, Brazil
307 Hospital of PLA
🇨🇳Beijing, China
Kobe City Medical Center General Hospital
🇯🇵Kobe-city, Japan
West China Hospital of Sichuan University
🇨🇳Chengdu, China
Guangdong General Hospital
🇨🇳Guangzhou, China
Local Institution - 600
🇨🇳Guangzhou, China
The First Affiliated Hospital of Medical School of Zhejiang University
🇨🇳Hangzhou City, China
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, China
Charite - Universitaetsmedizin Berlin Campus Virchow Klinikum
🇩🇪Berlin, Germany
Krankenhaus Nordwest
🇩🇪Frankfurt, Germany
Fakultni nemocnice Kralovske Vinohrady, Interni hematologicka klinika
🇨🇿Prague 10, Czechia
Klinkum der Stadt Villingen-Schwenningen GmbH
🇩🇪Villingen-Schwenningen, Germany
Onkologische Schwerpunktpraxis Leer - Emden
🇩🇪Leer, Germany
UZ Gent
🇧🇪Gent, Belgium
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, China
CHU d'Angers
🇫🇷Angers, France
Peking Union Medical College Hospital
🇨🇳Beijing, China
Local Institution - 534
🇨🇿Praha, Czechia
Vseobecna Fakultni Nemocnice v Praze
🇨🇿Praha, Czechia
MS INCA HC I Hospital do Cancer I
🇧🇷Rio De Janeiro, Brazil
Sociedade Beneficente de Senhoras Hospital Sirio Libanes
🇧🇷São Paulo, Brazil
Centre Hospitalier Universitaire d'Avicennes
🇫🇷Bobigny Cedex, France
Soroka University Medical Center
🇮🇱Beer Sheva, Israel
Hadassah University Hospital
🇮🇱Jerusalem, Israel
The Third Xiangya hospital of central south university
🇨🇳Changsha, China
CHRU de Brest - Hopital Morvan
🇫🇷Brest Cedex, France
Jiangsu Province Hospital The First Hospital affiliated with Nanjing Medical University
🇨🇳Nanjing, China
Peking University People's Hospital
🇨🇳Beijing, China
CHU de Poitiers
🇫🇷Poitiers, France
Charite - Universitaetsmedizin Berlin Charité - Campus Benjamin Franklin
🇩🇪Berlin, Germany
Interni hematoonkologicka klinika
🇨🇿Brno, Czechia
Kliniken Maria Hilf GmbH
🇩🇪Mönchengladbach, Germany
Hopital Saint-Louis
🇫🇷Paris, France
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, China
Istituto Europeo di Oncologia - IEO
🇮🇹Milano, Italy
Fakultni Nemocnice Ostrava, Klinika hematoonkologie,
🇨🇿Ostrava, Czechia
Fakultni nemocnice Hradec Kralove, IV.interni hematologicka klinika
🇨🇿Hradec Kralove, Czechia
MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Eastbourne District General Hospital
🇬🇧Eastbourne, United Kingdom
19 Mayis Medical Faculty - Samsun
🇹🇷Samsun, Turkey
Mitchell Cancer Center, University of South Alabama
🇺🇸Mobile, Alabama, United States
Arizona Center for Cancer Care
🇺🇸Glendale, Arizona, United States
Southwest Cancer Care Medical Group
🇺🇸Escondido, California, United States
Marin Oncology Associates
🇺🇸Greenbrae, California, United States
Wilshire Oncology Medical Group, Inc
🇺🇸La Verne, California, United States
North County Hematology Oncology (NCHO) - TRM, LLC.
🇺🇸Oceanside, California, United States
Hematology-Oncology Medical Group of Orange County, Inc.
🇺🇸Orange, California, United States
Central Coast Medical Oncology Corporation
🇺🇸Santa Maria, California, United States
Cancer Center of Central Connecticut
🇺🇸Southington, Connecticut, United States
Wellness Hematology Oncology
🇺🇸West Hills, California, United States
Illinois Cancer Care, P.C.
🇺🇸Peoria, Illinois, United States
Florida Cancer Specialists North Region Sarah Cannon Research
🇺🇸Saint Petersburg, Florida, United States
LRG Healthcare Oncology Clinic
🇺🇸Laconia, Indiana, United States
Iowa Oncology Research Association
🇺🇸Des Moines, Iowa, United States
Providence Cancer Institute
🇺🇸Southfield, Michigan, United States
University of Louisville, J.G. Brown Cancer Center
🇺🇸Louisville, Kentucky, United States
Coborn Cancer Center at the St. Cloud Hospital
🇺🇸Saint Cloud, Minnesota, United States
NH Oncology - Hematology, PA
🇺🇸Hooksett, New Hampshire, United States
The Cancer Center at Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Hematology-Oncology Associates of Northern NJ
🇺🇸Morristown, New Jersey, United States
University of New Mexico
🇺🇸Albuquerque, New Mexico, United States
Weill Cornell Medical College
🇺🇸New York, New York, United States
Ospedale degli Infermi di Rimini
🇮🇹Rimini, Italy
Chugoku Central Hospital
🇯🇵Hiroshima, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa, Japan
Local Institution - 513
🇵🇱Warszawa, Poland
The Cancer Institute Hospital of Japanese Foundation For Cancer Research
🇯🇵Koto-ku, Japan
University Hospital, Kyoto Prefectural University of Medicine
🇯🇵Kyoto-city, Japan
Toranomon Hospital
🇯🇵Minato-ku, Japan
National University Corporation Tohoku University, Tohoku University Hospital
🇯🇵Sendai-shi, Japan
Instituto Portugues de Oncologia de Lisboa, Francisco Gentil
🇵🇹Lisboa, Portugal
Local Institution - 330
🇵🇹Lisboa, Portugal
Local Institution - 331
🇵🇹Porto, Portugal
Hospital Auxilio Muto Centro de Cancer
🇵🇷San Juan, Puerto Rico
Krasnoyarsk Regional Clinical Hospital
🇷🇺Krasnoyarsk, Russian Federation
Russian Academy of Medical Sciences Institution
🇷🇺Moscow, Russian Federation
St. Petersburg Pavlov State Medical University
🇷🇺St.Petersburg, Russian Federation
Moscow State Medical Institution Municipal Clinical Hospital n.a. S.P. Botkin
🇷🇺Moscow, Russian Federation
Federal Centre of Heart, Blood and Endocrinology of Rosmed technlologies V.A. Almazov
🇷🇺St Petersburg, Russian Federation
The Ministry of Health and Social Development of the Tula region state institution Health Tula regio
🇷🇺Tula, Russian Federation
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitario Reina Sofia
🇪🇸Córdoba, Spain
Local Institution - 314
🇪🇸Córdoba, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Costa del Sol
🇪🇸Marbella, Spain
Local Institution - 315
🇪🇸Marbella, Spain
Cancer Hospital, Fudan University
🇨🇳Shanghai, China
Hospital Morales Meseguer
🇪🇸Murcia, Spain
Chinese Academy of Medical Sciences & Peking Union Medical College
🇨🇳Tianjin, China
Tianjin Medical University Cancer Institute and Hospital
🇨🇳Tianjin, China
Local Institution - 318
🇪🇸Murcia, Spain
Local Institution - 311
🇪🇸Salamanca, Spain
Cukurova University Medical Faculty Balcali Hospital
🇹🇷Adana, Turkey
Hospital Universitario Virgen Del Rocio
🇪🇸Sevilla, Spain
Hacettepe Universitesi
🇹🇷Ankara, Turkey
Pamukkale University Medical Faculty
🇹🇷Denizli, Turkey
Gaziantep University
🇹🇷Gaziantep, Turkey
Kocaeli Derince Training and Research Hospital
🇹🇷Umuttepe Kocaeli, Turkey
Marmara University
🇹🇷Istanbul, Turkey
Dokuz Eylul University Izmir
🇹🇷Izmir, Turkey
Royal Liverpool University Hospital, Prescot Street
🇬🇧Liverpool, United Kingdom
Barts Cancer Institute, Queen Mary University of London, Charterhouse Square
🇬🇧London, United Kingdom
Southend University Hospital NHS Foundation Trust, Prittlewell Chase
🇬🇧Westcliff on Sea, United Kingdom
Hospital de Clínicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Associacao Educudora Sao Carlos AESC Hospital Giovanni Battista HGB Hospital Mae de Deus Center
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Associacao Hospitalar Moinhos de Vento Hospital Moinhos de Vento
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Centro di Riferimento Oncologico - IRCCS
🇮🇹Aviano (PN), Italy
U.O.C. Ematologia
🇮🇹Barletta, Italy
A.O.U. di Bologna Policlinico S.Orsola-Malpighi
🇮🇹Bologna, Italy
Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi - Nesima
🇮🇹Catania, Italy
Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori (I.R.S.T.)
🇮🇹Meldola, Italy
Ospedale Niguarda Ca Granda
🇮🇹Milano, Italy
IRCCS- Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione "G. Pascale"
🇮🇹Napoli, Italy
Az. Osp. Vincenzo Cervello
🇮🇹Palermo, Italy
Casa di Cura La Maddalena
🇮🇹Palermo, Italy
Azienda Ospedaliero-Universitaria di Parma
🇮🇹Parma, Italy
Ospedale di Ravenna
🇮🇹Ravenna, Italy
Azienda Ospedaliera Bianchi-Melacrino-Morelli
🇮🇹Reggio Calabria, Italy
Azienda Ospedaliera S. Andrea - Università La Sapienza
🇮🇹Roma, Italy
Fundacao Pio XII - Hospital de Cancer de Barretos
🇧🇷Barretos, São Paulo, Brazil
AZ St-Jan Brugge Oostende AV
🇧🇪Brugge, Belgium
Hospital Dr. Amaral Carvalho/ Hospital Amaral Carvalho Jaú
🇧🇷Jau/SP, São Paulo, Brazil
St Francis Hospital
🇺🇸Greenville, South Carolina, United States
Spartanburg Regional Healthcare System - Gibbs Cancer Center & Research Institute
🇺🇸Spartanburg, South Carolina, United States
Malopolskie Centrum Medyczne S.C.
🇵🇱Kraków, Poland
AZ Groeninge
🇧🇪Kortrijk, Belgium
Tel-Aviv Sourasky Medical Center
🇮🇱Tel-Aviv, Israel
CHU Mont -Godinne
🇧🇪Yvoir, Belgium
Local Institution - 708
🇯🇵Nagasaki-shi, Nagasaki, Japan
Local Institution - 709
🇯🇵Minato-ku, Tokyo, Japan
National Cancer Center Hospital
🇯🇵Chuo-ku, Japan
Nagoya Medical Center,Division of Hematology/Oncology
🇯🇵Nagoya, Japan
Local Institution - 700
🇯🇵Koto-ku, Japan
The Japanese Red Cross Nagasaki Genbaku Hospital
🇯🇵Nagasaki, Japan
Instytut Hematologii i Transfuzjologii w Warszawie
🇵🇱Warszawa, Poland
Local Institution - 514
🇵🇱Warszawa, Poland
Centrum Onkologii, Instytut im. Marii Sklodowskiej-Curie
🇵🇱Warszawa, Poland
Instituto Portugues de Oncologia do Porto, Francisco Gentil
🇵🇹Porto, Portugal
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Oncology Hematology Care Sarah Cannon Research
🇺🇸Cincinnati, Ohio, United States
Local Institution - 028
🇺🇸Portland, Oregon, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Sarah Cannon Research Inst
🇺🇸Nashville, Tennessee, United States
Hospital Universitario de Salamanca
🇪🇸Salamanca, Spain
Local Institution - 340
🇮🇹Roma, Italy
UC Davis Medical Center
🇺🇸Sacramento, California, United States
Wake Forest Baptist Health
🇺🇸Winston-Salem, North Carolina, United States