Postoperative Nausea and Vomiting: Ramosetron Plus Aprepitant vs Palonosetron Plus Aprepitant
Not Applicable
Completed
- Conditions
- Postoperative Nausea and Vomiting
- Interventions
- Registration Number
- NCT02597907
- Lead Sponsor
- Kyungpook National University Hospital
- Brief Summary
The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.
- Detailed Description
The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.
Study is performed during 24 hours after surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 88
Inclusion Criteria
- Non smoking, female patients, scheduled for laparoscopic cholecystectomy
Exclusion Criteria
- Patients with gastrointestinal disorder,
- Patients with allergies to any study medication,
- Patients who had received any sedatives, opioid, steroid or antiemetics within 24 h before surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description aprepitant plus ramosetron aprepitant aprepitant 80 mg ramosetron 0.3 mg aprepitant plus palonosetron aprepitant aprepitant 80 mg palonosetron 0.075 mg aprepitant plus palonosetron palonosetron aprepitant 80 mg palonosetron 0.075 mg aprepitant plus ramosetron Ramosetron aprepitant 80 mg ramosetron 0.3 mg
- Primary Outcome Measures
Name Time Method The Incidence of Postoperative Nausea and Vomiting 24 hours The incidence of postoperative nausea and vomiting during 24 hours postoperatively
- Secondary Outcome Measures
Name Time Method