The efficacy of a vitamin C rich guava fruit in improving iron absorption from mungbean based meals: a stable isotope study

Completed

Conditions: mineralen absorptie aandoeningen
iron absorption
iron bioavailability

Registration Number: NL-OMON33466

Lead Sponsor: Wageningen Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

Age 18-40 years
Body weight < 65 kg;
Non pregnant, non lactating and not planning to become pregnant
Apparetly healthy, free of chronic illnesses and not taking chronic medication.
No medication nor supplemental iron at time of entry into the study.
No intake of vitamin and mineral supplements in the last 2 weeks prior the study, or willigness to discontinue.
Subject has not made blood donation in the last 6 months
Subjects that in the past did not participate in studies with administration of stable isotope labels in the past (iron).

Exclusion Criteria

Younger than 18 years of age and older than 40 years of age
Post menopausal
Using medicinal iron or related preparations
Body weight > 65kg
Pregnant or lactating
People consuming chronic medication
Use of vitamin and mineral supplements
Blood donation in the last 6 months
Subjects that in the past participated in studies with administration of stable isotope labels (iron).

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Assessment of the incorporation of 57Fe related to 58Fe into erythrocytes 14 d<br /><br>after administration and calculated based on isotope-dilution. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Whole blood will be collected at recruitment for the analysis of Hb, Hb type,<br /><br>serum ferritin (SF), transferrin receptor (TfR), C-reactive protein (CRP),<br /><br>erythropoietin (Epo), serum iron (SI), total iron binding capacity (TIBC), and<br /><br>transferrin saturation (TfSat). Anemia will be defined as a hemoglobin<br /><br>concentration < 120 g/L, and iron deficiency will be defined as an SF<br /><br>concentration < 12 µg/L. </p><br>