A Comparative study of 0.5% hyperbaric Levobupivacaine and 0.5% hyperbaric Bupivacaine for spinal anaesthesia in elective lower segment casearean sections
Trial Snapshot
- Phase
- Unknown
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- To compare various effects of intrathecal 0.5% Hyperbaric Levobupivacaine & 0.5%hyperbaric Bupivacaine in elective lower segment casearean sections
Study Overview
Brief Summary
Spinal anaesthesia is the most common anesthesia used in elective and emergency lower segment casearean sections.Hyperbaric solutions are generally preferred in subarachnoid block because they provide sufficient block and do not cause high block levels commonly
Bupivacaine has R and S enantiomers they have different affinity on sodium and potassium channels.S enantiomers are relatively less cardiotoxic and neurotoxic.In recent studies Levobupivacaine as safer alternative for regional anesthesia than racemic Bupivacaine.
Hence we aim to study hyperbaric Levobupivacaine 0.5%, and Hyperbaric Bupivacaine 0.5%, with respect to hemodynamic changes,block characteristics, postoperative complications
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 40.00 Year(s) (—)
- Sex
- Female
Inclusion Criteria
- •1.Patients undergoing elective lower segment casearean sections from 18-40years age 2.ASA physical status II.
Exclusion Criteria
- •1.Patients with ASA physical status III,IV 2.Patients having any contraindications to spinal anaesthesia 3.Patients with history of allergy to local anaesthetic.
Outcomes
Primary Outcomes
To compare various effects of intrathecal 0.5% Hyperbaric Levobupivacaine & 0.5%hyperbaric Bupivacaine in elective lower segment casearean sections
Time Frame: At Oth minute immediately & then 3 6 9 15 20 25 30 45 60 75 90
1.Hemodynamic changes
Time Frame: At Oth minute immediately & then 3 6 9 15 20 25 30 45 60 75 90
Secondary Outcomes
- Sensory & motor blockade characteristics(At 5minutes)