Diet and Health in Adults with Metabolic Syndrome
- Conditions
- Metabolic Syndrome
- Interventions
- Dietary Supplement: Higher protein, low glycemic load diet
- Registration Number
- NCT03935048
- Lead Sponsor
- University of Arkansas, Fayetteville
- Brief Summary
The prevalence of US adults with Metabolic Syndrome (MetS) is over 34%, impacting nearly 35% of all adults and 50% of those aged 60 years or older. MetS is characterized as a combination of underlying risk factors that when, occurring together, increase the risk for chronic diseases such as type 2 diabetes mellitus (T2DM), cardiovascular disease, stroke, and certain types of cancer, resulting in an 1.6-fold increase in mortality. According the American Heart Association, health risks associated with Metabolic Syndrome can be significantly reduced by reducing body weight and eating a diet that is rich in whole grains, fruits, and vegetables. Potatoes (e.g. skin-on white potatoes) are an excellent source of potassium, vitamin C, and vitamin B6 and a good source of magnesium and dietary fiber. In addition, the potato has greater dry matter and protein per unit growing area compared with cereals. Despite this, consumers tend to believe that potatoes are high in calories and in fat compared with other carbohydrate sources such as rice or pasta, an incorrect assumption since a potato has negligible fat and a low energy density similar to legumes. Data from short-term nutrition intervention trials, suggest that potatoes consumed as part of a low-glycemic load meal can play a role in the prevention or treatment of MetS. However, the impact of long-term potato consumption on cardiometabolic risk factors associated with MetS is not known. Therefore, there is a critical need to determine if regular (\> 4 times per week) potato consumption can improve cardiometabolic health in individuals with MetS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 90
- Resides in Northwest Arkansas
- Age 18+ years
- Metabolic Syndrome (characterized by participant having three or more of the following measurements: abdominal obesity, triglyceride level over 150 mg/dl, HDL cholesterol < 40 mg/dl in men and 50 mg/dl in women, systolic blood pressure of 130 mm Hg or diastolic blood pressure of 85 mm Hg, and/or fasting glucose > 100 mg/dL)
- All ethnicities
- Female and male
- Currently consuming a high glycemic load diet
- Food allergies
- Dietary restrictions (e.g. vegetarian, vegan, etc.)
- Trying to lose weight in last 3 months
- Prescription medications related to heart disease or type 2 diabetes
- Fear of needles
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Higher Protein, Low Glycemic Load with Potatoes Higher protein, low glycemic load diet Higher Protein, Low Glycemic Load with Potatoes (HPLG-P): low- to moderate- glycemic load meals containing white potatoes. Participants will consume low- to moderate-glycemic meals for 16 weeks and will need to consume at least 4 meals containing white potatoes. Higher Protein, Low Glycemic Load - Control Higher protein, low glycemic load diet Higher Protein, Low Glycemic Load (HPLG-C): low- to moderate- glycemic load meals containing control carbohydrate (e.g. rice, pasta). Participants will consume low- to moderate-glycemic meals for 16 weeks and will need to consume at least 4 meals containing control carbohydrate sources. Higher Protein, Low Glycemic Load with Processed Potatoes Higher protein, low glycemic load diet Higher Protein, Low Glycemic Load with Processed Potatoes (HPLG-PP): low- to moderate- glycemic load meals containing processed white potato products. Participants will consume low- to moderate-glycemic meals for 16 weeks and will need to consume at least 4 meals containing white potatoes.
- Primary Outcome Measures
Name Time Method Plasma glucose levels Change from baseline at 16 weeks Plasma glucose levels
Serum lipid levels Change from baseline at 16 weeks Total Cholesterol, LDL-Cholesterol, HDL-Cholesterol, Free Fatty Acids, Triglycerides
- Secondary Outcome Measures
Name Time Method Dietary intake Change of time of study (16 weeks) Monthly food records will be recorded to determine changes in diet intake
Mood Change from baseline at 16 weeks Mood will be measured using the Profile of Mood States questionnaire
Waist circumference Change from baseline at 16 weeks Waist circumference in centimeters
Sleep duration Change from baseline at 16 weeks Sleep duration will be assessed using an Actigraph sleep monitor
Sleep quality and duration Change from baseline at 16 weeks Sleep quality will be assessed using the Pittsburgh Sleep Quality Index
Marker of appetite and sleep Change from baseline at 16 weeks Orexin (also known as hypocretin)
Appetite Change from baseline at 16 weeks Anorexigenic appetite hormone - PYY (peptide tyrosine tyrosine)
Trial Locations
- Locations (1)
University of Arkansas
🇺🇸Fayetteville, Arkansas, United States