The effect of high dose statins (Simvastatin 80 mg) on vascular inflammation in the abdominal aneurysm.
Recruiting
- Conditions
- Abdominal Aortic Aneurysm
- Registration Number
- NL-OMON24165
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
1. Age >18;
2. Open elective AAA repair;
Exclusion Criteria
1. Statin intolerance;
2. Renal impairment (clearance <30 ml/min);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Aortic wall IL6, IL8 and MCP-1 levels.
- Secondary Outcome Measures
Name Time Method 1. Aortic wall cell counts;<br /><br>2. Aortic wall protease expression;<br /><br>3. Aortic wall transcription factor activation.<br>