COMPARISON BETWEEN TWO DRUGS TO CHECK THE EFFECTIVENESS ON HEMODYNAMIC PARAMETERS

Phase 3

Not yet recruiting

• Conditions: ATTENUATION DURING ANESTHESIA IN LAPROSCOPIC CHOLECYSTECTOMY

• Registration Number: CTRI/2018/07/014901
• Lead Sponsor: SSG HOSPITAL VADODARA

Brief Summary

70 patients of ASA status 1 and 2 ,aged between 18 to 65 years ,of either sex ,scheduled for laparoscopic cholecystectomy were randomized in 2 groups (group D and group M)in a single blind fashion ,to receive either dexmedetomidine1mcg/kg,magnesium sulphate 40mg/kg in normal saline iv respectively .Total volume of the study drug was adjusted to 20 ml and administered over 15 mins before induction .Aesthesia was induced with propofol till loss of eyelid reflex followed by inj succinylcholine 2mg/kg. Laryngoscopy  and intubation were done with appropriate size mac intosh blade and endotracheal tube .Hemodynamic parameters of patients including HR,SBP,RPP,MAP,SPO2,ETCO2,ECG were recorded at different time interval as below           1 baseline           2 before ad after infusion           3 after intubation           4 after pneumoperitoneum           5 after release of pneumoperitoneum           6 after extubation.

Post operative sedation and analgesia were assessed.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2018-07-13
• Study Start: 2018-07-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1Age Group 18 -65years 2ASA status I & II 3Male / female Patients posted for laparoscopic cholecystectomy.

Exclusion Criteria

•Anticipated difficult airway and obesity •Patient having allergy to study drug •Patient with systemic diseases like severe hypertension, cardiovascular, respiratory, neurological, psychological, hepatic, renal disease (diagnosed by clinical judgments and investigations) and on medication of above mentioned diseases •Patients with heart rate <60 beats/mi •Pregnant or lactating females •Patients who refuse to give consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It will be expected that both drugs will be effectively able to attenuate hemodynamic stress response during anaesthesia for laparoscopic cholecystectomy with CO2 pneumoperitoneum	1.Baseline | 2.Before and after infusion | 3.Before and after intubation | 4.Before and after Pneumoperitoneum | 5.After release of Pneumoperitoneum | 6.After Extubation

Secondary Outcome Measures

Name	Time	Method
1Amount of induction agent used	2Post-operative sedation –Ramsay sedation score

Trial Locations

Locations (1)

SSG HOSPITAL ,VADODARA; 🇮🇳 Vadodara, GUJARAT, India

SSG HOSPITAL ,VADODARA

🇮🇳Vadodara, GUJARAT, India

SHAILEE SHAH

Principal investigator

9737458589

dr.shahshailee16@gmail.com