Medical Marijuana and Its Effects on Motor Function in People With Multiple Sclerosis

Completed

• Conditions: Multiple Sclerosis
• Interventions: Behavioral: Medical Marijuana

• Registration Number: NCT02898974
• Lead Sponsor: Colorado State University

Brief Summary

Medical marijuana is commonly prescribed people with Multiple Sclerosis (MS) for symptom, e.g. spasticity and pain, management. Unfortunately not much is known about its effects outside the treatment for these 2 symptoms. Several previous studies have suggested people with MS using medical marijuana have lower levels of physical disability and improved walking abilities. A major limitation of these previous studies is that the investigators used subjective measures of motor function. In this proposed observational case-control study the investigators plan to objectively measure multiple domains of motor function, such as: fatigue, strength, and walking ability. No marijuana will be brought on to campus or given to participants.

Detailed Description

To investigate the effects of medical marijuana usage on physical function the investigators will employ an observational case-control design. Cases (MS medical marijuana users) will be compared to age, sex, and disease duration matched controls (MS non-cannabis users).

Study Timeline

• Study Start: 2016-09
• Study First Submitted: 2016-09-06
• Study First Submitted QC: 2016-09-08
• Study First Posted: 2016-09-13
• Primary Completion: 2017-10
• Study Completion: 2017-10
• Results First Submitted: 2018-07-26
• Status Verified: 2019-02
• Results First Submitted QC: 2020-01-31
• Last Update Submitted: 2020-01-31
• Results First Posted: 2020-02-05
• Last Update Posted: 2020-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Medically diagnosed with MS,
• 30-60 years of age,
• Moderate disability (Patient Determined Disease Steps score 2-6).

Exclusion Criteria

• Relapse with the last 60 days,
• High risk for cardiovascular disease (American College of Sports Medicine risk classification),
• Changes in disease modifying medications within the last 45 days,
• Concurrent neurological/neuromuscular disease,
• Hospitalization within the last 90 days,
• Inability to understand/sign informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Regular Medical Marijuana users	Medical Marijuana	People with MS that are regular Medical Marijuana users

Primary Outcome Measures

Name	Time	Method
Muscle Strength	Through study completion, an average of 6 months.	Maximal muscle strength measured with force transducer
Postural Stability	Through study completion, an average of 6 months.	Timed up and go
Fatigue	Through study completion, an average of 6 months.	Strength decline during fatiguing muscle contraction measured with force transducer

Trial Locations

Locations (1)

Department of Health and Exercise Science; 🇺🇸 Fort Collins, Colorado, United States