Gamma Knife Radiosurgery on Tectal Plate Gliomas

Completed

• Conditions: Gamma Knife Radiosurgery; Tectal Plate Gliomas

• Registration Number: NCT07015710
• Lead Sponsor: Al-Azhar University

Brief Summary

This study aimed to assess the impact of gamma knife radiosurgery on tectal plate gliomas (TPGs).

Detailed Description

Tectal plate gliomas (TPGs) represent a subset of brainstem gliomas that are predominantly slow-growing, low-grade tumors and rarely produce neurological deficits.

Viable options include biopsy and monitoring with serial neuroimaging, surgical resection, radiotherapy (either early following surgery or late on evidence of disease progression), chemotherapy, and stereotactic radiosurgery (SRS).

SRS using Gamma Knife radiosurgery (GKRS) has been identified in small case series as a safe and promising approach for managing TPGs that necessitate intervention beyond mere observation.

Study Timeline

• Study Start: 2021-01-01
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01
• Status Verified: 2025-06
• Study First Submitted: 2025-06-03
• Study First Submitted QC: 2025-06-03
• Last Update Submitted: 2025-06-03
• Study First Posted: 2025-06-11
• Last Update Posted: 2025-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age from 5 to 55 years.
• Both sexes.
• Patients underwent gamma knife radiosurgery (GKRS) for tectal plate gliomas (TPGs).

Exclusion Criteria

• High-grade glioma.
• Tumor extension beyond the tectal region.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of response	One year post-procedure	Incidence of response was recorded.

Trial Locations

Locations (1)

Al-Azhar University (Damietta); 🇪🇬 Damietta, Egypt