Glycemic and Insulinemic Responses of Low-Carbohydrate Snack Foods

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Blueberry Cake; Other: Glucose Solution First Repeat; Other: Glucose Solution Second Repeat; Other: Snacks with Cheese; Other: Spicy Crackers

• Registration Number: NCT04175496
• Lead Sponsor: TC Erciyes University

Brief Summary

The aim of this study is develop recipes containing CHO less than ICR, prepare new snacks alternatives that could be consumed without need for additional insulin doses, and evaluate the glycemic and insulinemic responses of these recipes. A randomized crossover trial will include 15 healthy adults aged 19-30 years. All participants will consume 3 test foods and reference food (glucose solution, 2 times) in a random order. Blood samples will be collected at time points 0,15, 30, 45, 60, 90 and 120 min. Glucose and insulin analyzes will be performed from blood samples. The results of these time points will be marked on the chart and the incremental area under the curve (iAUC) will be calculated for both glucose and insulin.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-11-21
• Study First Submitted QC: 2019-11-21
• Study First Posted: 2019-11-25
• Study Start: 2019-12-01
• Primary Completion: 2020-03-01
• Study Completion: 2020-04-01
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-06
• Last Update Posted: 2021-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy volunteer
• Normal body weight (18.5-25 kg / m2 BMI)
• 19-30 years old

Exclusion Criteria

• use of tobacco,
• weight change of >5 kg in the last 3 months
• the presence of any chronic disease or lactose intolerance,
• regular medicine use,
• pregnancy or lactation,
• performing competitive sports or endurance sports,
• fasting plasma glucose concentration >100 mg / dL,
• the presence of eating disorder,
• sensitivity or allergies to any food that used in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Test Foods	Spicy Crackers	Blueberry Cake, Snack with Cheese and spicy Crackers will be used as test foods.
Test Foods	Blueberry Cake	Blueberry Cake, Snack with Cheese and spicy Crackers will be used as test foods.
Reference Food	Glucose Solution Second Repeat	Glucose solution will use as reference food.
Test Foods	Snacks with Cheese	Blueberry Cake, Snack with Cheese and spicy Crackers will be used as test foods.
Reference Food	Glucose Solution First Repeat	Glucose solution will use as reference food.

Primary Outcome Measures

Name	Time	Method
Postprandial glucose response	two hours postprandial period	Postprandial glucose response will be quantified as incremental area under the curve (iAUC) (mg/dL x minutes), which is calculated according to the trapezoidal rule by using blood glucose values at time points 0, 15, 30, 45, 60, 90, and 120 minutes.
Postprandial insulin response	two hours postprandial period	Postprandial insulin response will be quantified as incremental area under the curve (iAUC) (mg/dL x minutes), which is calculated according to the trapezoidal rule by using blood glucose values at time points 0, 15, 30, 45, 60, 90, and 120 minutes.

Trial Locations

Locations (1)

Erciyes University Faculty of Health Sciences; 🇹🇷 Kayseri, Turkey