Effects of the Combining Physical Exercise and Cognitive Training for the Community-based Elderly
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cognitively-normal
- Sponsor
- Chang Gung Memorial Hospital
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Change scores of the Montreal Cognitive Assessment (MoCA).
- Last Updated
- 4 years ago
Overview
Brief Summary
This study aims to (1) determine the intervention effects of sequential and simultaneous training on cognitive function and health-related function for cognitively-normal elderly and elderly with Mild Cognitive Impairment(MCI) and Subjective Cognitive Decline(SCD); (2) compare which combination approach is more advantageous for improvement on outcome measures.
Detailed Description
The investigators will recruit 30 cognitively-normal elderly and 30 elderly with Mild Cognitive Impairment(MCI) and 30 elderly with Subjective Cognitive Decline(SCD). Participants will be randomly assigned to one of three groups: sequential training (first perform physical exercise followed by cognitive training), simultaneous training (perform physical exercise and cognitive tasks simultaneously), and control group (perform body stretching and health education courses). All participants will receive trainings for 120 minutes per day, one day per week for 12 weeks. The outcome will include measurements that evaluate the cognitive, physical, daily functions, quality of life, and social participation. Participants will be assessed at baseline, after the intervention, and at 3-month follow-up. Repeated measures of analysis of variance (ANOVA) will be used to evaluate the changes in outcome measures at three different time points for the elderly with cognitively-normal, Mild Cognitive Impairment(MCI) and Subjective Cognitive Decline(SCD), respectively. The investigators also use the analysis of covariance (ANCOVA) to investigate the differences between the Mild Cognitive Impairment(MCI) and Subjective Cognitive Decline(SCD) groups on the outcome measures.
Investigators
Eligibility Criteria
Inclusion Criteria
- •able to follow instruction
- •not SCD or MCI or Dementia
Exclusion Criteria
- •concomitant neurological conditions such as dementia, Parkinson's disease, brain tumor, brain injury and other brain diseases (such as intracranial hypertension or cerebral edema);
- •have unstable cardiovascular status such as uncontrolled hypertension
- •Inclusion Criteria:
- •SCD(from Ecog-12)
- •not MCI or Dementia
- •Exclusion Criteria:
- •concomitant neurological conditions such as dementia, Parkinson's disease, brain tumor, brain injury and other brain diseases (such as intracranial hypertension or cerebral edema);
- •have unstable cardiovascular status such as uncontrolled hypertension
- •Inclusion Criteria:
- •(1)age\>=60 (2)20 ≦MoCA \< 26 (3)MCI (3)not Dementia
Outcomes
Primary Outcomes
Change scores of the Montreal Cognitive Assessment (MoCA).
Time Frame: baseline, after the intervention eight weeks, and at 3-month follow-up.
The Montreal Cognitive Assessment (MoCA) will be used to assess general cognitive functions. It examines several cognitive domains with a total score of 30 and higher values indicate better cognitive functions. The MoCA has been shown to be a valid and promising tool to evaluate the global cognitive function in patients with stroke. The psychometric properties of MoCA are good to excellent for patients with cerebrovascular diseases.
Change scores of Color trials test
Time Frame: baseline, after the intervention eight weeks, and at 3-month follow-up.
For Part 1, the respondent uses a pencil to rapidly connect circles numbered 1-25 in sequence. For Part 2, the respondent rapidly connects numbered circles in sequence, but alternates between pink and yellow. The length of time to complete each trial is recorded, along with qualitative features of performance indicative of brain dysfunction, such as near-misses, prompts, number sequence errors, and color sequence errors.
Change scores of Wechsler Memory Scale (WMS)
Time Frame: baseline, after the intervention eight weeks, and at 3-month follow-up.
including Faces Recognition (total scale=48), Verbal Paired Associates (total scale = 32), Word Lists (total scale = 48), and Spatial Span (total scale=32) will be used to assess the immediate, delayed, and working memory tests. For each subtest, a higher number indicates better performance in memory function. The raw score of subtests will also be transferred to standardized Z scores and summed to represent an index of general memory function.
Change scores of Stroop test
Time Frame: baseline, after the intervention eight weeks, and at 3-month follow-up.
The participants will be tested under congruent and incongruent conditions. In the congruent condition, the participant will name the color ink of a word which is consistent with the written color name; whereas in the incongruent condition the participant will name the color ink differs from the written color name. The time to complete the task will be calculated for each condition
Secondary Outcomes
- Change scores of Verbal fluency tests(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of the short (12-item) form of the Everyday Cognition Scale (ECog-12)(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Wechsler Adult Intelligence Scale; WAIS(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Six-minute walk test,6MWT(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of International Physical Activity Questionnaires (IPAQ)(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of the World Health Organization Quality of Life-Old(WHOQOL-OLD)(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Timed up and go (TUG)(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of 30 second chair stand test,CST(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Grip strength(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of The Clinical Frailty Scale (CFS)(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Dual-task tests(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of short physical performance battery,SPPB(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Reported Edmonton Frail Scale (REFS)(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Amsterdam Instrumental Activity of Daily Living,A-IADL(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Geriatric Depression Scale,GDS(baseline, after the intervention eight weeks, and at 3-month follow-up.)
- Change scores of Community Integration Questionnaire, CIQ(baseline, after the intervention eight weeks, and at 3-month follow-up.)