Prevalence and Longitudinal Follow-up Over 2 Years of Anal Lesions, HPV Infection and Associated Sexually Transmitted Infections Among Men Who Have Sex With Men (MSM) in Lomé, Togo
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Prevalence at inclusion of anal lesions
研究概览
简要总结
The DepIST-H study, funded by the French AIDS and Hepatitis Research Agency (ANRS), is to estimate prevalence (the number of cases over a given period of time) and incidence (the number of new cases over a given period of time) of anal lesions (condylomas, dysplasia, cancers) by HIV status among MSM in Lomé, Togo
详细描述
Title: Prevalence and longitudinal follow-up over 2 years of anal lesions, HPV infection and associated sexually transmitted infections among men who have sex with men (MSM) in Lomé, Togo (ANRS12400 DepIST-H)
Main objective: To estimate the prevalence and incidence of anal lesions (condyloma, dysplasia and anal cancers) according to HIV status among MSM in Lomé, Togo
Specific objectives :
To estimate the prevalence of HPV infection at baseline (M0) at anal and oropharyngeal sites To describe the persistence of HPV infection at Year 1 and 2 at the anal and oropharyngeal sites To describe the recurrence of anal lesions at Year 1 and 2 To estimate prevalence and incidence of associated STIs (Neisseria gonorrhoeae, Chlamydia trachomatis, Herpes simplex Virus type 2, Mycoplasma genitalium, Trichomonas vaginalis) HBV, HCV and syphilis
Methods :
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Being a male aged 18 or over
- •Self-reporting as being a MSM
- •Wishing to be part of a regular clinical follow-up
- •Agreeing to participate in the study and signing the informed consent form
- •Live in Lomé
- •Having had anal intercourse within the past six months prior to inclusion visit
- •Regardless of HIV status (infected or not)
- •Whether or not the participant has already taken antiretrovirals
排除标准
- •Participation in another biomedical and/or behavioural study on HIV, viral hepatitis or sexually transmitted infections (CohMSM ANRS 12324-EF cohort of Lomé)
结局指标
主要结局
Prevalence at inclusion of anal lesions
时间窗: at Day 0
According to HIV status among MSM in Lomé, Togo
次要结局
- Incidence of HPV infection(at 12 month and 24 month)
- Describe the proportion of clearance of HPV infections(at 12 month and 24 month)
- Describe the number of worsening events of anal cytological lesions(at 12 month and 24 month)
- Prevalence of anal lesions at baseline(at Day 0)
- Incidence of anal lesions(at 12 month and 24 month)
- Prevalence of HPV infections(at Day 0)
- Describe the proportion of persistent HPV infections(at 12 month and 24 month)
- Describe the proportion of recurrence of anal lesions(at 12 month and 24 month)